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Human Chromogranin A Partial [19-457] Recombinant Protein C- His Tag

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Product nameHuman Chromogranin A Partial [19-457] Recombinant Protein C- His Tag
Uniprot IDP10645
Uniprot linkhttp://www.uniprot.org/uniprot/P10645
Origin speciesHomo sapiens (Human)
Expression systemProkaryotic expression
SequenceMGLPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRGLEHHHHHH
Molecular weight68.16KDa
Protein delivered with Tag?Yes
Purity estimated90%
BufferTris 50mMand 500mM Nacl pH7.5
FormLyophilized
Delivery conditionDry Ice
Delivery lead time in business days10-25
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesEscherichia coli (E.coli)
ApplicationsELISA,WB
Fragment TypePartial
Protein AccessionNP_001266.1
Spec:Entrez GeneID1113
Spec:NCBI Gene AliasesCGA
Spec:SwissProtIDP10645
Aliases /SynonymsChromograninA Partial [19-457], chromogranin A (parathyroid secretory protein 1), CHGA, Pituitary secretory protein I, SP-I,
ReferencePX-P2060
NoteFor research use only
Datasheet Download
MSDS Download

Publication

  • 1: Shanahan MA, Salem A, Fisher A, Cho CS, Leverson G, Winslow ER, Weber SM. Chromogranin A predicts survival for resected pancreatic neuroendocrine tumors. J Surg Res. 2016 Mar;201(1):38-43. doi: 10.1016/j.jss.2015.10.006. Epub 2015 Oct 11. PubMed PMID: 26850182.
  • 2: Khan TM, Garg M, Warner RR, Uhr JH, Divino CM. Elevated Serum Pancreastatin Is an Indicator of Hepatic Metastasis in Patients With Small Bowel Neuroendocrine Tumors. Pancreas. 2016 Aug;45(7):1032-5. doi: 10.1097/MPA.0000000000000572. PubMed PMID: 26684860.
  • 3: Mir SA, Zhang K, Milic M, Gu Y, Rieg T, Ziegler M, Vaingankar SM. Analysis and validation of traits associated with a single nucleotide polymorphism Gly364Ser in catestatin using humanized chromogranin A mouse models. J Hypertens. 2016 Jan;34(1):68-78. doi: 10.1097/HJH.0000000000000760. PubMed PMID: 26556564.
  • 4: Kaiserova M, Prikrylova Vranova H, Galuszka J, Stejskal D, Mensikova K, Zapletalova J, Mares J, Kanovsky P. Orthostatic hypotension is associated with decreased cerebrospinal fluid levels of chromogranin A in early stage of Parkinson disease. Clin Auton Res. 2015 Oct;25(5):339-42. doi: 10.1007/s10286-015-0302-1. Epub 2015 Sep 10. PubMed PMID: 26359267.
  • 5: Choi Y, Miura M, Nakata Y, Sugasawa T, Nissato S, Otsuki T, Sugawara J, Iemitsu M, Kawakami Y, Shimano H, Iijima Y, Tanaka K, Kuno S, Allu PK, Mahapatra NR, Maeda S, Takekoshi K. A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population. Endocr J. 2015;62(9):797-804. doi: 10.1507/endocrj.EJ14-0471. Epub 2015 Jul 25. PubMed PMID: 26211667.
  • 6: Qi S, Huang M, Teng H, Lu Y, Jiang M, Wang L, Shi J, Ma Q, Gu G, Xin Y, Ma H. Autoantibodies to chromogranin A are potential diagnostic biomarkers for non-small cell lung cancer. Tumour Biol. 2015 Dec;36(12):9979-85. doi: 10.1007/s13277-015-3794-3. Epub 2015 Jul 18. PubMed PMID: 26186986.
  • 7: Yang X, Yang Y, Li Z, Cheng C, Yang T, Wang C, Liu L, Liu S. Diagnostic value of circulating chromogranin a for neuroendocrine tumors: a systematic review and meta-analysis. PLoS One. 2015 Apr 20;10(4):e0124884. doi: 10.1371/journal.pone.0124884. eCollection 2015. Review. PubMed PMID: 25894842; PubMed Central PMCID: PMC4403810.
  • 8: Zhu D, Xie H, Wang X, Liang Y, Yu H, Gao W. Correlation of plasma catestatin level and the prognosis of patients with acute myocardial infarction. PLoS One. 2015 Apr 7;10(4):e0122993. doi: 10.1371/journal.pone.0122993. eCollection 2015. PubMed PMID: 25848973; PubMed Central PMCID: PMC4388679.
  • 9: Wolf M, Riedlinger I, Lehmann R, Häring HU, Schleicher E, Peter A. Comparison of the automated KRYPTOR chromogranin A assay with the DAKO ELISA. Clin Lab. 2014;60(12):2103-6. PubMed PMID: 25651748.
  • 10: Brehm Hoej L, Parkner T, Soendersoe Knudsen C, Grønbaek H. A comparison of three chromogranin A assays in patients with neuroendocrine tumours. J Gastrointestin Liver Dis. 2014 Dec;23(4):419-24. doi: 10.15403/jgld.2014.1121.234.3ca. PubMed PMID: 25532001.
  • 11: Wang YH, Yang QC, Lin Y, Xue L, Chen MH, Chen J. Chromogranin A as a marker for diagnosis, treatment, and survival in patients with gastroenteropancreatic neuroendocrine neoplasm. Medicine (Baltimore). 2014 Dec;93(27):e247. doi: 10.1097/MD.0000000000000247. PubMed PMID: 25501094; PubMed Central PMCID: PMC4602794.
  • 12: Chou WC, Chen JS, Hung YS, Hsu JT, Chen TC, Sun CF, Lu CH, Hwang TL. Plasma chromogranin A levels predict survival and tumor response in patients with advanced gastroenteropancreatic neuroendocrine tumors. Anticancer Res. 2014 Oct;34(10):5661-9. PubMed PMID: 25275071.
  • 13: Hijioka M, Ito T, Igarashi H, Fujimori N, Lee L, Nakamura T, Jensen RT, Takayanagi R. Serum chromogranin A is a useful marker for Japanese patients with pancreatic neuroendocrine tumors. Cancer Sci. 2014 Nov;105(11):1464-71. doi: 10.1111/cas.12533. Epub 2014 Oct 18. PubMed PMID: 25220535; PubMed Central PMCID: PMC4462381.
  • 14: Mazzawi T, Gundersen D, Hausken T, El-Salhy M. Increased gastric chromogranin A cell density following changes to diets of patients with irritable bowel syndrome. Mol Med Rep. 2014 Nov;10(5):2322-6. doi: 10.3892/mmr.2014.2498. Epub 2014 Aug 18. PubMed PMID: 25174455; PubMed Central PMCID: PMC4214334.
  • 15: Qiao XW, Qiu L, Chen YJ, Meng CT, Sun Z, Bai CM, Zhao DC, Zhang TP, Zhao YP, Song YL, Wang YH, Chen J, Lu CM. Chromogranin A is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumors but not for insulinomas. BMC Endocr Disord. 2014 Aug 7;14:64. doi: 10.1186/1472-6823-14-64. PubMed PMID: 25099181; PubMed Central PMCID: PMC4130880.
  • 16: Dominguez N, Estevez-Herrera J, Borges R, Machado JD. The interaction between chromogranin A and catecholamines governs exocytosis. FASEB J. 2014 Nov;28(11):4657-67. doi: 10.1096/fj.14-249607. Epub 2014 Jul 30. PubMed PMID: 25077558.
  • 17: Burgio SL, Conteduca V, Menna C, Carretta E, Rossi L, Bianchi E, Kopf B, Fabbri F, Amadori D, De Giorgi U. Chromogranin A predicts outcome in prostate cancer patients treated with abiraterone. Endocr Relat Cancer. 2014 May 8;21(3):487-93. doi: 10.1530/ERC-14-0071. Print 2014 Jun. PubMed PMID: 24741024.

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