Microtubule-associated protein tau(MAPT)(1-441)

Description of Microtubule-associated protein tau(MAPT)(1-441)

General Information about Microtubule-associated protein tau (MAPT)

Microtubule-associated protein tau (MAPT) promotes microtubule assembly and stability, and may participate in the establishment and maintenance of neuronal polarity. The C-terminus binds to axon microtubules, while the N-terminus binds to the plasma membrane components, indicating that tau acts as a linker between the two. Axon polarity is predetermined by the TAU/MAPT positioning (in neuronal cells) in the cell body domain defined by the centrosome. The short isoform can make the cytoskeleton plastic, while the longer isoform can give priority to its stabilizing effect.