EGFR / ERBB1 / HER1, C-His, recombinant protein

Reference: PX-P5701-100
Product nameEGFR / ERBB1 / HER1, C-His, recombinant protein
Origin speciesHomo sapiens (Human)
Expression systemEukaryotic expression
Molecular weight134.29 kDa
Protein delivered with Tag?C-terminal His Tag
Purity estimated>90% as determined by SDS-PAGE
BufferPBS, pH7.5
Delivery conditionDry Ice
Delivery lead time in business days3-5 days if in stock; 3-5 weeks if production needed
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesMammalian cells
ApplicationsELISA,WB
Fragment TypeMet1-Ser645
Protein AccessionP00533
ReferencePX-P5701
NoteFor research use only.

Description of EGFR / ERBB1 / HER1, C-His, recombinant protein

General information on EGFR / ERBB1 / HER1, C-His, recombinant protein

Structure

EGFR (Epidermal Growth Factor Receptor, also known as ERBB1 or HER1) is a transmembrane receptor tyrosine kinase, composed of an extracellular ligand binding domain, a transmembrane region and an intracellular tyrosine kinase domain.

Activity

EGFR is activated by binding of its ligand, epidermal growth factor (EGF). This binding causes a conformational change in the receptor, leading to autophosphorylation of its tyrosine kinase domain and the initiation of downstream signaling pathways.

Application

EGFR is involved in a variety of cellular processes, including cell proliferation, differentiation, and migration. It is also a target for antibody-drug conjugates, which are used in the treatment of various cancers.

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