Recombinant Human FBLN5, N-His

Description of Recombinant Human FBLN5, N-His

Introduction

Recombinant Human FBLN5, also known as Fibulin-5, is a protein that plays a crucial role in maintaining the structural integrity of tissues and organs. It is a member of the fibulin family of extracellular matrix proteins and is encoded by the FBLN5 gene. Recombinant Human FBLN5 is produced through genetic engineering techniques, making it a valuable tool in various research and medical applications.

Structure of Recombinant Human FBLN5

Recombinant Human FBLN5 is a 63 kDa protein consisting of 448 amino acids. It has a modular structure, with an N-terminal fibulin-type module, followed by 9 calcium-binding EGF-like domains and a C-terminal fibulin-type module. The fibulin-type modules are responsible for binding to other extracellular matrix proteins, while the EGF-like domains play a role in cell signaling and adhesion. The calcium-binding sites are crucial for the stability and function of the protein.

Activity of Recombinant Human FBLN5

Recombinant Human FBLN5 is primarily involved in maintaining the structural integrity of tissues and organs. It is a key component of elastic fibers, which are essential for the elasticity and resilience of tissues such as skin, blood vessels, and lungs. FBLN5 also plays a role in cell adhesion and migration, as well as regulating cell signaling pathways.

Studies have shown that FBLN5 deficiency can lead to various diseases and disorders, such as age-related macular degeneration, aortic aneurysms, and skin disorders. Recombinant Human FBLN5 has been used in research to better understand the role of this protein in these conditions and to develop potential treatments.

Application of Recombinant Human FBLN5

Recombinant Human FBLN5 has a wide range of applications in both research and medical fields. One of the primary uses of this protein is in studying the structure and function of elastic fibers. By producing recombinant FBLN5, researchers can study the effects of mutations or modifications on the protein’s activity and its role in various diseases.

In the medical field, Recombinant Human FBLN5 has shown promise as a potential therapeutic agent. Studies have demonstrated its ability to promote wound healing and tissue regeneration, making it a potential treatment for skin disorders and injuries. FBLN5 has also been investigated as a potential treatment for aortic aneurysms, as it has been found to improve the stability of the aortic wall and prevent further expansion of the aneurysm.

Conclusion

Recombinant Human FBLN5 is a crucial protein in maintaining the structural integrity of tissues and organs. Its modular structure and various functions make it a valuable tool in research and medical applications. By producing recombinant FBLN5, scientists can gain a better understanding of its role in various diseases and potentially develop new treatments. With ongoing research, the potential applications of Recombinant Human FBLN5 are continuously expanding, making it an important protein in the field of biotechnology.