Recombinant Human CD49f/ITGA6 Protein, N-His

Description of Recombinant Human CD49f/ITGA6 Protein, N-His

Introduction

Recombinant Human CD49f/ITGA6 Protein is a protein that plays a crucial role in cell adhesion and migration. It is a member of the integrin family of proteins, which are cell surface receptors that mediate cell-extracellular matrix interactions. This protein is encoded by the ITGA6 gene and is also known as CD49f or alpha-6 integrin.

Structure of Recombinant Human CD49f/ITGA6 Protein

Recombinant Human CD49f/ITGA6 Protein is a transmembrane glycoprotein consisting of two subunits, alpha-6 and beta-1. The alpha-6 subunit contains a large extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. The beta-1 subunit, on the other hand, has a small extracellular domain, a single transmembrane domain, and a long cytoplasmic tail. The two subunits are non-covalently linked, forming a heterodimeric protein with a total molecular weight of approximately 150 kDa.

The extracellular domain of Recombinant Human CD49f/ITGA6 Protein contains several functional domains, including an I domain, an EGF-like domain, and four fibronectin type III domains. These domains are responsible for binding to different ligands, such as laminin, collagen, and fibronectin, which are components of the extracellular matrix.

Activity of Recombinant Human CD49f/ITGA6 Protein

Recombinant Human CD49f/ITGA6 Protein plays a critical role in cell adhesion and migration. It is expressed on the surface of various cell types, including epithelial cells, endothelial cells, and immune cells. This protein interacts with its ligands on the extracellular matrix, promoting cell attachment and spreading.

One of the main functions of Recombinant Human CD49f/ITGA6 Protein is to mediate cell adhesion to laminin, a major component of the basement membrane. This interaction is crucial for the maintenance of epithelial cell integrity and barrier function. In addition, this protein also plays a role in cell migration, as it is involved in the formation of focal adhesions and the regulation of actin cytoskeleton dynamics.

Moreover, Recombinant Human CD49f/ITGA6 Protein has been shown to be involved in various cellular processes, including cell proliferation, differentiation, and survival. It has also been implicated in the regulation of immune responses, as it is expressed on the surface of immune cells and can modulate their functions.

Application of Recombinant Human CD49f/ITGA6 Protein

Recombinant Human CD49f/ITGA6 Protein has a wide range of applications in both research and clinical settings. One of the main applications of this protein is in the study of cell adhesion and migration. Its role in these processes makes it a valuable tool for investigating various cellular mechanisms and pathways.

In addition, Recombinant Human CD49f/ITGA6 Protein has been used in the development of therapeutic strategies for various diseases. For example, it has been targeted for the treatment of cancer, as it is involved in tumor cell invasion and metastasis. By blocking the interaction of this protein with its ligands, it is possible to inhibit cancer cell migration and invasion, thereby preventing the spread of cancer.

Furthermore, Recombinant Human CD49f/ITGA6 Protein has also been utilized in tissue engineering and regenerative medicine. Its ability to promote cell adhesion and migration makes it a valuable component in the development of biomaterials for tissue repair and regeneration.

Conclusion

In summary, Recombinant Human CD49f/ITGA6 Protein is an essential protein involved in cell adhesion and migration. Its structure, activity, and various applications make it a valuable tool in scientific research and a potential target for therapeutic interventions. Further studies on this protein may provide new insights into its functions and potential applications in