Recombinant Human TAC1 Protein, N-His-SUMO

Description of Recombinant Human TAC1 Protein, N-His-SUMO

Introduction

Recombinant Human TAC1 protein, also known as Substance P, is a neuropeptide that plays a crucial role in the regulation of pain and inflammation. It is produced by the gene TAC1 and is a member of the tachykinin family of peptides. Recombinant Human TAC1 protein has been extensively studied and has shown promising potential for therapeutic applications in various diseases.

Structure of Recombinant Human TAC1 Protein

Recombinant Human TAC1 protein is composed of 11 amino acids and has a molecular weight of approximately 1.2 kDa. It is a linear polypeptide with a conserved C-terminal sequence of -Phe-X-Gly-Leu-Met-NH2. The structure of Recombinant Human TAC1 protein is highly conserved among different species, indicating its essential role in physiological processes.

Activity of Recombinant Human TAC1 Protein

Recombinant Human TAC1 protein acts as a neurotransmitter and neuromodulator in the central and peripheral nervous systems. It binds to the neurokinin-1 (NK-1) receptor, a G protein-coupled receptor, and triggers a cascade of signaling events that result in the activation of various cellular pathways. This leads to the release of other neurotransmitters and neuropeptides, ultimately regulating pain and inflammation.

One of the main activities of Recombinant Human TAC1 protein is its role in pain transmission. It is released from sensory nerve endings in response to noxious stimuli and acts on the NK-1 receptor to transmit pain signals to the central nervous system. Recombinant Human TAC1 protein is also involved in neurogenic inflammation, where it promotes vasodilation and increases vascular permeability, leading to the recruitment of immune cells to the site of injury or infection.

Moreover, Recombinant Human TAC1 protein has been shown to play a crucial role in the regulation of immune responses. It can induce the production and release of cytokines, chemokines, and growth factors from immune cells, thereby modulating the immune response. This activity of Recombinant Human TAC1 protein has been implicated in various diseases, including autoimmune disorders, allergies, and cancer.

Applications of Recombinant Human TAC1 Protein

Recombinant Human TAC1 protein has diverse applications in both basic research and clinical settings. Its role in pain and inflammation makes it an attractive target for the development of pain-relieving drugs. Several studies have shown that blocking the NK-1 receptor or inhibiting the release of Recombinant Human TAC1 protein can reduce pain and inflammation in various animal models.

In addition, Recombinant Human TAC1 protein has been studied for its potential in the treatment of various diseases. Its ability to modulate immune responses makes it a promising candidate for the development of immunotherapies for autoimmune disorders and allergies. Moreover, Recombinant Human TAC1 protein has been investigated as a potential biomarker for cancer, as its levels have been found to be elevated in certain types of cancer.

Furthermore, Recombinant Human TAC1 protein has been used in research to study the role of neuropeptides in various physiological and pathological processes. Its availability as a recombinant protein allows for easy manipulation and investigation of its structure and function. Recombinant Human TAC1 protein has also been utilized in the development of diagnostic assays for the detection of pain and inflammatory disorders.

Conclusion

In conclusion, Recombinant Human TAC1 protein is a crucial neuropeptide that plays a significant role in pain and inflammation. Its structure, activity, and potential applications have been extensively studied, and it has shown promising results in various disease conditions. Further research and development of Recombinant Human TAC1 protein may lead to the development of novel therapeutics for pain, inflammation, and immune-related disorders.