Recombinant Human NFIL3 Protein, N-His-SUMO & C-Strep

Description of Recombinant Human NFIL3 Protein, N-His-SUMO & C-Strep

Introduction to Recombinant Human NFIL3 Protein

Recombinant Human NFIL3 Protein, also known as Nuclear Factor Interleukin-3 Regulated Protein (NFIL3), is a protein that plays a crucial role in regulating gene expression and cell growth. It is produced through recombinant DNA technology, making it a highly pure and specific protein for various scientific applications. In this article, we will explore the structure, activity, and applications of Recombinant Human NFIL3 Protein.

Structure of Recombinant Human NFIL3 Protein

Recombinant Human NFIL3 Protein is a transcription factor that belongs to the basic leucine zipper (bZIP) family. It is composed of 676 amino acids and has a molecular weight of approximately 75 kDa. The protein contains a DNA-binding domain, a leucine zipper domain, and a transactivation domain. The DNA-binding domain allows NFIL3 to bind to specific DNA sequences, while the leucine zipper domain is responsible for dimerization with other proteins. The transactivation domain is crucial for activating the expression of target genes.

Activity of Recombinant Human NFIL3 Protein

Recombinant Human NFIL3 Protein is a transcription factor that regulates the expression of various genes involved in cell growth, differentiation, and apoptosis. It binds to specific DNA sequences known as NFIL3 response elements (NREs) and activates or represses the transcription of target genes. NFIL3 is known to interact with other proteins and form heterodimers, which further enhances its transcriptional activity.

NFIL3 is also involved in regulating the immune response by controlling the production of cytokines, such as interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF). These cytokines play a crucial role in the development and function of immune cells, making NFIL3 an essential protein in the immune system.

Moreover, NFIL3 has been found to play a role in maintaining the balance between cell proliferation and apoptosis. It can promote cell proliferation by activating the expression of genes involved in cell cycle progression, while also inducing cell death by repressing the expression of anti-apoptotic genes. This dual role of NFIL3 makes it a critical regulator of cell growth and survival.

Applications of Recombinant Human NFIL3 Protein

Recombinant Human NFIL3 Protein has various applications in the field of research and medicine. It is commonly used as an antigen in studies related to the immune system and cancer. NFIL3 has been found to be overexpressed in certain types of cancer, and its inhibition has shown promising results in suppressing tumor growth. Researchers also use recombinant NFIL3 to study the role of this protein in immune cell development and function.

Moreover, NFIL3 is a potential target for drug development, as its dysregulation has been linked to various diseases, including autoimmune disorders, inflammation, and neurological disorders. By understanding the structure and activity of NFIL3, scientists can design drugs that specifically target this protein and treat these diseases effectively.

In addition, recombinant NFIL3 is also used in gene therapy studies. By introducing the NFIL3 gene into cells, researchers can manipulate its activity and regulate the expression of target genes. This technique has shown promising results in treating genetic disorders and other diseases caused by gene mutations.

Conclusion

In summary, Recombinant Human NFIL3 Protein is a crucial protein involved in regulating gene expression and cell growth. Its structure and activity make it an essential player in various biological processes, including immune response, cell proliferation, and apoptosis. With its diverse applications in research and medicine, NFIL3 continues to be a subject of interest for scientists, and further studies on this protein will provide valuable insights into its role in health and disease.