Recombinant Human G0S2 Protein, N-His-SUMO & C-Strep

Description of Recombinant Human G0S2 Protein, N-His-SUMO & C-Strep

Introduction to Recombinant Human G0S2 Protein

Recombinant Human G0S2 Protein is a type of protein that is produced through genetic engineering techniques. It is a member of the G0/G1 switch gene family and is involved in regulating cell cycle progression and metabolism. G0S2 has been found to play a crucial role in various cellular processes, making it a valuable tool for scientific research and potential therapeutic applications.

Structure of Recombinant Human G0S2 Protein

The gene encoding for G0S2 is located on chromosome 1 in humans and consists of 2 exons and 1 intron. The protein itself is composed of 103 amino acids with a molecular weight of approximately 12 kDa. It has a highly conserved structure, with a predicted alpha-helical transmembrane domain and a C-terminal hydrophobic region. The N-terminal region of G0S2 contains a conserved sequence that is responsible for its function in regulating cell cycle progression.

Activity of Recombinant Human G0S2 Protein

G0S2 has been found to have a wide range of activities in different cellular processes. Its main function is to regulate cell cycle progression by inhibiting the activity of cyclin-dependent kinases (CDKs). CDKs are enzymes that control the progression of the cell cycle by phosphorylating specific target proteins. G0S2 acts as a negative regulator of CDKs, preventing the cell from entering the S phase of the cell cycle.

In addition to its role in cell cycle regulation, G0S2 has also been shown to have an impact on lipid metabolism. It has been found to inhibit the activity of lipases, enzymes responsible for breaking down lipids. This results in the accumulation of lipids in the cell, which can have implications for various metabolic disorders.

Furthermore, G0S2 has been implicated in the regulation of apoptosis, or programmed cell death. It has been found to interact with Bcl-2, a protein that plays a crucial role in apoptosis. G0S2 has been shown to inhibit the anti-apoptotic activity of Bcl-2, leading to increased cell death.

Application of Recombinant Human G0S2 Protein

The unique activities of G0S2 make it a valuable tool for scientific research and potential therapeutic applications. Recombinant Human G0S2 Protein can be used in various in vitro and in vivo studies to gain a better understanding of its role in cell cycle regulation, lipid metabolism, and apoptosis. It can also be used to study the potential therapeutic benefits of targeting G0S2 in certain diseases.

One potential therapeutic application of G0S2 is in cancer treatment. As G0S2 inhibits the activity of CDKs, it has the potential to be used as a targeted therapy to prevent cancer cells from proliferating. It has also been found to be overexpressed in certain types of cancer, making it a potential biomarker for diagnosis and treatment.

In addition, the role of G0S2 in lipid metabolism makes it a potential target for metabolic disorders such as obesity and diabetes. By inhibiting the activity of lipases, G0S2 can regulate lipid accumulation and potentially improve metabolic health.

Conclusion

Recombinant Human G0S2 Protein is a valuable tool for scientific research and has potential therapeutic applications. Its unique structure and activities make it a promising target for various diseases, particularly in cancer and metabolic disorders. Further studies on G0S2 will continue to expand our understanding of its role in cellular processes and its potential for therapeutic interventions.