Recombinant Mouse IL23R Protein, N-His

Description of Recombinant Mouse IL23R Protein, N-His

Introduction

Recombinant Mouse IL23R Protein, also known as Interleukin 23 Receptor, is a protein that plays a crucial role in the immune system. It is a transmembrane protein that is encoded by the IL23R gene in mice. This protein is a member of the cytokine receptor family and is involved in the signaling pathway of the cytokine Interleukin 23 (IL-23). In this article, we will discuss the structure, activity, and application of Recombinant Mouse IL23R Protein.

Structure of Recombinant Mouse IL23R Protein

Recombinant Mouse IL23R Protein is a type I cytokine receptor that is composed of 629 amino acids. It has a molecular weight of approximately 69 kDa. The protein consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains two fibronectin type III domains, which are responsible for ligand binding. The transmembrane domain is a hydrophobic region that anchors the protein to the cell membrane. The intracellular domain contains a conserved region known as the “Toll/IL-1 receptor” (TIR) domain, which is involved in signal transduction.

Activity of Recombinant Mouse IL23R Protein

Recombinant Mouse IL23R Protein acts as a receptor for the cytokine IL-23, which is produced by activated dendritic cells and macrophages. Upon binding to IL-23, the receptor undergoes conformational changes, leading to the activation of the TIR domain. This results in the recruitment of intracellular signaling molecules, such as the Janus kinase (JAK) family of proteins. The JAK proteins then phosphorylate the intracellular domain of the receptor, which creates binding sites for the transcription factor STAT3. The activated STAT3 then translocates to the nucleus, where it regulates the expression of genes involved in immune responses.

Application of Recombinant Mouse IL23R Protein

Recombinant Mouse IL23R Protein has various applications in both research and therapeutic settings.

Research Applications

One of the main research applications of Recombinant Mouse IL23R Protein is its use in studying the signaling pathway of IL-23. Researchers can use this protein to investigate the interaction between the receptor and its ligand, as well as the downstream signaling events. This can provide valuable insights into the role of IL-23 in immune responses and diseases.

Another research application of Recombinant Mouse IL23R Protein is its use in screening potential drugs or compounds that can modulate the activity of the IL-23/IL-23R pathway. This can aid in the development of new treatments for diseases such as autoimmune disorders and cancer, which are associated with dysregulation of this pathway.

Therapeutic Applications

Recombinant Mouse IL23R Protein has potential therapeutic applications due to its role in regulating immune responses. It has been shown to play a crucial role in the development of autoimmune diseases, such as inflammatory bowel disease and psoriasis. Therefore, targeting the IL-23/IL-23R pathway with therapeutic agents, such as antibodies or small molecules, can be a promising approach for treating these diseases.

Moreover, Recombinant Mouse IL23R Protein can also be used in immunotherapy for cancer. IL-23 has been shown to have both pro- and anti-tumor effects, and targeting the IL-23/IL-23R pathway can potentially enhance anti-tumor immune responses. This makes Recombinant Mouse IL23R Protein a potential therapeutic target for cancer treatment.

Conclusion

In summary, Recombinant Mouse IL23R Protein is a transmembrane protein that plays a crucial role in the immune system. Its structure consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The protein acts as a receptor for the cytokine IL-23 and is involved in