Recombinant Human ACBD5 Protein, N-His

Description of Recombinant Human ACBD5 Protein, N-His

Introduction to Recombinant Human ACBD5 Protein

The use of recombinant proteins has revolutionized the field of biotechnology, allowing for the production of large quantities of specific proteins for various applications. One such protein is Recombinant Human ACBD5 Protein, which has gained significant attention in recent years due to its unique structure and diverse range of activities. In this article, we will explore the structure, activity, and applications of Recombinant Human ACBD5 Protein in detail.

Structure of Recombinant Human ACBD5 Protein

ACBD5 (Acyl-CoA binding domain-containing protein 5) is a member of the ACBD family of proteins, which are involved in lipid metabolism and intracellular transport. The human ACBD5 gene is located on chromosome 19 and encodes a protein of 253 amino acids. Recombinant Human ACBD5 Protein is produced by cloning the human ACBD5 gene into an expression vector and expressing it in a suitable host system, such as E. coli or mammalian cells.

The primary structure of Recombinant Human ACBD5 Protein contains an N-terminal acyl-CoA binding domain (ACBD) and a C-terminal ankyrin repeat domain (ANK). The ACBD domain is responsible for binding to various acyl-CoA molecules, while the ANK domain is involved in protein-protein interactions. The tertiary structure of Recombinant Human ACBD5 Protein has been determined through X-ray crystallography, revealing a compact, globular structure with the ACBD and ANK domains located in close proximity to each other.

Activity of Recombinant Human ACBD5 Protein

Recombinant Human ACBD5 Protein has been shown to have a diverse range of activities, making it a valuable tool for various research and industrial applications. The primary function of ACBD5 is to bind to and transport acyl-CoA molecules, which are essential for lipid metabolism and energy production. In addition, Recombinant Human ACBD5 Protein has been found to interact with other proteins involved in lipid metabolism, such as DGAT2 and FABP3, suggesting a role in regulating lipid homeostasis.

Moreover, studies have also demonstrated that Recombinant Human ACBD5 Protein plays a role in intracellular vesicle trafficking, particularly in the transport of cholesterol and fatty acids. This function is crucial for maintaining cellular membrane integrity and has implications in various diseases, such as atherosclerosis and cancer.

Applications of Recombinant Human ACBD5 Protein

The unique structure and diverse activities of Recombinant Human ACBD5 Protein make it a valuable tool for various applications in the fields of biotechnology and medicine. One of the primary applications of this protein is in the production of therapeutic antibodies. Recombinant Human ACBD5 Protein has been shown to enhance the production and secretion of monoclonal antibodies, making it a promising candidate for improving antibody-based therapies.

In addition, Recombinant Human ACBD5 Protein has also been used in the development of biosensors for the detection of various biomolecules, such as cholesterol and fatty acids. These biosensors utilize the binding properties of ACBD5 to detect and quantify specific molecules, making them useful for diagnostic and research purposes.

Furthermore, the role of Recombinant Human ACBD5 Protein in lipid metabolism and vesicle trafficking has also sparked interest in its potential as a therapeutic target for various diseases. Studies have shown that ACBD5 plays a role in the development of atherosclerosis and cancer, making it a potential target for drug development.

Conclusion

In conclusion, Recombinant Human ACBD5 Protein is a versatile protein with a unique structure and diverse range of activities. Its ability to bind to acyl-CoA molecules and interact with other proteins involved in lipid metabolism and vesicle trafficking make it a valuable tool for various applications in biotechnology and medicine. As research on this protein continues