Recombinant Mouse CD102/ICAM2 Protein, N-His

Description of Recombinant Mouse CD102/ICAM2 Protein, N-His

Introduction to Recombinant Mouse CD102/ICAM2 Protein

Recombinant Mouse CD102/ICAM2 Protein, also known as intercellular adhesion molecule 2 (ICAM-2), is a cell surface glycoprotein that plays a crucial role in immune response and cell adhesion. It is a member of the immunoglobulin superfamily and is expressed on various cell types, including leukocytes, endothelial cells, and epithelial cells. The recombinant form of this protein has been widely used in research and therapeutic applications due to its structural and functional properties.

Structure of Recombinant Mouse CD102/ICAM2 Protein

The recombinant form of CD102/ICAM2 protein is a 55 kDa glycoprotein with a molecular weight of approximately 50-60 kDa. It is composed of 9 extracellular Ig-like domains, a transmembrane region, and a short cytoplasmic tail. The extracellular domains are responsible for the binding of various ligands, including leukocyte integrins, and are highly conserved among species. The transmembrane region anchors the protein to the cell membrane, while the cytoplasmic tail is involved in signal transduction.

Activity of Recombinant Mouse CD102/ICAM2 Protein

Recombinant Mouse CD102/ICAM2 Protein is a key player in the immune response and cell adhesion processes. It functions as a ligand for leukocyte integrins, such as LFA-1 and Mac-1, and mediates leukocyte-endothelial cell adhesion. This interaction is crucial for leukocyte recruitment to sites of inflammation and for the activation of immune responses. Additionally, CD102/ICAM2 protein is involved in the regulation of leukocyte migration, proliferation, and survival.

Moreover, recombinant CD102/ICAM2 protein has been shown to have anti-inflammatory properties. It can inhibit the production of pro-inflammatory cytokines, such as TNF-α and IL-6, and promote the production of anti-inflammatory cytokines, such as IL-10. This makes it a potential therapeutic target for inflammatory diseases.

Applications of Recombinant Mouse CD102/ICAM2 Protein

Recombinant Mouse CD102/ICAM2 Protein has a wide range of applications in both research and therapeutic settings. In research, it is commonly used as an antigen for the production of monoclonal antibodies. These antibodies can then be used for various applications, such as flow cytometry, immunohistochemistry, and Western blotting, to study the expression and function of CD102/ICAM2 protein.

Furthermore, recombinant CD102/ICAM2 protein has been used in in vitro studies to investigate its role in immune response and cell adhesion. It has also been used to develop in vivo animal models to study its function in disease processes, such as inflammation and autoimmune disorders.

In therapeutic applications, recombinant CD102/ICAM2 protein has shown promising results in the treatment of inflammatory diseases. It has been used as a potential therapeutic target for diseases such as rheumatoid arthritis, multiple sclerosis, and asthma. Additionally, it has been explored as a potential target for anti-cancer therapy, as it has been shown to inhibit tumor growth and metastasis.

Conclusion

In summary, Recombinant Mouse CD102/ICAM2 Protein is a 55 kDa glycoprotein that plays a crucial role in immune response and cell adhesion. Its structure, consisting of 9 extracellular Ig-like domains, a transmembrane region, and a short cytoplasmic tail, enables it to interact with various ligands and regulate immune and inflammatory processes. The recombinant form of this protein has been widely used in research and therapeutic applications, making it a valuable tool in the study and treatment of various diseases.