Recombinant Mouse Flt3 ligand/FLT3L Protein, N-His

Description of Recombinant Mouse Flt3 ligand/FLT3L Protein, N-His

Introduction

Recombinant Mouse Flt3 ligand/FLT3L Protein, also known as Flt3L, is a cytokine that plays a crucial role in hematopoiesis and immune system development. It is a recombinant protein that is produced through genetic engineering techniques, making it a valuable tool in various research and therapeutic applications. In this article, we will explore the structure, activity, and application of Recombinant Mouse Flt3 ligand/FLT3L Protein.

Structure of Recombinant Mouse Flt3 ligand/FLT3L Protein

Flt3L is a member of the hematopoietic growth factor family, which also includes cytokines such as GM-CSF, IL-3, and IL-6. It is a homodimeric protein consisting of two identical subunits, each containing 155 amino acids. The protein has a molecular weight of approximately 18 kDa and is glycosylated, meaning it has sugar molecules attached to it.

The crystal structure of Flt3L has been determined, revealing a compact globular structure with two antiparallel β-sheets and four α-helices. The two subunits are held together by disulfide bonds, forming a stable dimer. The glycosylation sites are located on the surface of the protein, which may play a role in its stability and activity.

Activity of Recombinant Mouse Flt3 ligand/FLT3L Protein

Flt3L is primarily known for its role in hematopoiesis, the process of blood cell formation. It acts as a growth factor for hematopoietic stem cells, promoting their proliferation and differentiation into various blood cell types, including white blood cells, red blood cells, and platelets.

Aside from its role in hematopoiesis, Flt3L also plays a crucial role in immune system development. It is a potent stimulator of dendritic cell production, which are important immune cells that initiate and regulate immune responses. Flt3L also promotes the maturation and activation of dendritic cells, making it a valuable tool in immunotherapy and vaccine development.

Application of Recombinant Mouse Flt3 ligand/FLT3L Protein

Recombinant Mouse Flt3 ligand/FLT3L Protein has a wide range of applications in both research and clinical settings. In research, it is commonly used to study hematopoiesis and immune system development. Its ability to stimulate the production and maturation of dendritic cells makes it a valuable tool in immunology research, particularly in the development of new immunotherapies and vaccines.

In the clinical setting, Flt3L has been investigated as a potential treatment for various diseases. It has shown promising results in clinical trials for the treatment of acute myeloid leukemia (AML) and other hematological malignancies. Flt3L has also been studied as a potential adjuvant in cancer immunotherapy, as it can enhance the immune response against tumor cells.

Conclusion

In summary, Recombinant Mouse Flt3 ligand/FLT3L Protein is a cytokine that plays a crucial role in hematopoiesis and immune system development. Its compact globular structure and glycosylation make it a stable and active protein. Its ability to stimulate the production and maturation of dendritic cells has made it a valuable tool in research and clinical applications, particularly in the fields of immunology and cancer treatment. As research on Flt3L continues, it is expected to have even more significant impacts on various areas of medicine and biotechnology.