Recombinant Mouse LOXL2 Protein, N-His

Description of Recombinant Mouse LOXL2 Protein, N-His

Introduction

Recombinant Mouse LOXL2 Protein, also known as Lysyl oxidase-like 2 protein, is a member of the lysyl oxidase family of enzymes. This protein is encoded by the LOXL2 gene and is involved in the formation and maintenance of connective tissue in the body. Recombinant Mouse LOXL2 Protein is produced through a recombinant protein expression system, making it a valuable tool for scientific research and potential therapeutic applications.

Structure of Recombinant Mouse LOXL2 Protein

Recombinant Mouse LOXL2 Protein is a 96 kDa protein consisting of 774 amino acids. It contains a highly conserved catalytic domain, characterized by the presence of a copper-binding site and a lysyl tyrosyl quinone (LTQ) cofactor. This domain is responsible for the enzymatic activity of LOXL2, which is the oxidation of lysine residues in collagen and elastin fibers. The protein also has four scavenger receptor cysteine-rich (SRCR) domains, which are involved in protein-protein interactions and may play a role in the regulation of LOXL2 activity.

Activity of Recombinant Mouse LOXL2 Protein

The main function of LOXL2 is to catalyze the cross-linking of collagen and elastin fibers, which are essential components of connective tissue. This cross-linking process, known as oxidative deamination, is crucial for the structural integrity and stability of tissues such as skin, blood vessels, and cartilage. Recombinant Mouse LOXL2 Protein has been shown to have similar enzymatic activity as the endogenous LOXL2 protein, making it a valuable tool for studying the role of LOXL2 in tissue development and diseases.

In addition to its role in connective tissue formation, LOXL2 has also been implicated in various cellular processes such as cell adhesion, migration, and proliferation. These functions are mediated through interactions with other proteins, including integrins and growth factor receptors. Recombinant Mouse LOXL2 Protein can be used to study these interactions and their effects on cellular behavior.

Application of Recombinant Mouse LOXL2 Protein

Recombinant Mouse LOXL2 Protein has a wide range of applications in scientific research. Its ability to catalyze the cross-linking of collagen and elastin fibers makes it a valuable tool for studying the role of LOXL2 in tissue development and diseases such as fibrosis and cancer. The protein can also be used in drug discovery and development, as LOXL2 has been identified as a potential therapeutic target for these diseases.

Furthermore, Recombinant Mouse LOXL2 Protein can be used in cell culture studies to investigate its role in cellular processes such as adhesion, migration, and proliferation. It can also be used to study the effects of LOXL2 on the extracellular matrix and its interactions with other proteins.

In addition to its research applications, Recombinant Mouse LOXL2 Protein has potential therapeutic applications. Studies have shown that inhibiting LOXL2 activity can reduce fibrosis and tumor growth, making it a promising target for drug development. Recombinant Mouse LOXL2 Protein can be used in pre-clinical studies to evaluate the efficacy of potential LOXL2 inhibitors.

Conclusion

Recombinant Mouse LOXL2 Protein is a valuable tool for scientific research and potential therapeutic applications. Its structure, enzymatic activity, and various functions make it a versatile protein for studying tissue development and diseases. With its potential as a therapeutic target, Recombinant Mouse LOXL2 Protein holds promise for the development of new treatments for fibrosis and cancer.