Skip to main content

It looks like you are visiting from outside the EU. Switch to the US version to see local pricing in USD and local shipping.

Switch to US ($)
📢 -40% on Recombinant Antibody Production. Available until January 31, 2026 on your first order. Code: RECAB40

AI-Driven Affinity Maturation Services

Achieve up to 1,000-fold higher affinity in only 6 weeks.

Get a free quote

0
Up to 1000 fold affinity improvement
0 weeks
From sequence to improved antibody
0%
IP-free

An AI built on biology, not a black box

Many AI platforms act like black boxes: you feed in sequences, and out comes a prediction no one can explain. At ProteoGenix, biology comes first. Our models generate biologically interpretable insights instead of cryptic outputs.
What we actually analyze:

  • Precise epitope mapping
  • Strength and weakness of molecular interactions
  • Compatibility between binding partners
  • CDR conformational shifts via molecular-dynamics simulations

From these mechanistic insights, we design optimized sequences for affinity maturation.
In short: an AI built by biologists, for biologists fully aligned with our long-standing expertise in custom antibody development and engineering.

Optimize my sequence

A service that goes beyond affinity improvement

Boosting affinity is great, unless it wrecks other critical properties. We ensure mutations preserve or improve:

  • Developability
  • Manufacturability
  • Solubility
  • Stability
  • And other liabilities that can derail clinical progression

Our goal isn’t only to make your antibody bind better. It’s to reduce risk and accelerate your path toward clinical phases.

Tools for DNA analysis with PCR reaction, multipipette and 96-well plate

Unique AI + Wet Lab integration for validated affinity gains

Predicting a better structure is nice. Demonstrating it experimentally is better. We produce and test the top-ranked variants in vitro, using our proprietary high-throughput antibody production platform to ensure rapid and reliable evaluation.
Based on the results, we either:

  • Reinforce our models with experimental data for another optimization round, or
  • Deliver your purified, high-affinity antibody if you’re satisfied
Generic antibody image

Affinity improvement guaranteed

Our AI-driven affinity maturation service guarantees a minimum 10-fold affinity increase. In many projects, our optimization process has delivered improvements ranging from 100- to 1,000-fold.

Increase the affinity of my antibody

Even more reasons to choose ProteoGenix’s AI-driven affinity maturation service

  • All sequences are yours, with no strings attached.

Our AI-driven affinity maturation workflow

From your sequence to an optimized antibody in 6 weeks

AI-powered variant design
  • Epitope & paratope mapping based on 3D modelling, molecular docking, and proprietary AI software
  • Machine-learning–based affinity maturation guided by expert bioinformaticians
  • Multi-parameter sequence optimization (developability, stability, immunogenicity…)
Recombinant production of variants
  • High-throughput expression of 20 selected variants using our proprietary MultimAbXpress™ platform
  • Full QC
Variant analysis
  • ELISA titration for all variants
  • BLI-based KD measurement for up to 10 best performers

FAQ about our AI-powered affinity maturation service

Need a quote or more information? Contact us!

    Cart (0 Items)

    Your cart is currently empty.

    View Products