Margetuximab Biosimilar – Anti-ERBB2, EGFR2, CD340 mAb – Research Grade

Reference:
Product nameMargetuximab Biosimilar - Anti-ERBB2, EGFR2, CD340 mAb - Research Grade
SourceCAS 1350624-75-7
SpeciesChimeric
Expression systemMammalian cells
Purity>85%
BufferPBS buffer PH7.5
Delivery conditionBlue ice (+4°C)
Delivery Time3-5 days if in stock; 3-5 weeks if production needed
Storage conditionstore at -80°C
BrandProteoGenix
ApplicationsELISA,WB
Aliases /SynonymsMargetuximab,MGAH-22,ERBB2, EGFR2, CD340,anti-ERBB2, EGFR2, CD340
ReferencePX-TA1331
NoteFor research use only. Not suitable for clinical or therapeutic use.
IsotypeIgG1-kappa
ClonalityMonoclonal Antibody

Description of Margetuximab Biosimilar - Anti-ERBB2/EGFR2/CD340 mAb - Research Grade

General information on Anti-ERBB2/EGFR2/CD340[Homo sapiens] (Margetuximab) Monoclonal Antibody

Margetuximab is an Fc-engineered human/mouse chimeric anti-HER2 monoclonal antibody of isotype IgG1 kappa . Margetuximab targets the same epitope on the HER2 extracellular domain and hass the same activity as trastuzumab. However, margetuximab has a higher affinity for both CD16A variants and a weaker one to the inhibitory CD32B Fc receptor, thereby resulting in more efficient antibody-dependent cell-mediated cytotoxicity (ADCC) and higher efficacy compared to trastuzumab. Margetuximab has been marketed under the trade name Margenza.

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