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Product name | Stable Isotope Labeled Anti-RBD-4 antibody (Casirivimab) |
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Species | Homo sapiens |
Expression system | Mammalian |
Molecular weight | 150kDa |
Purity | 85% |
Buffer | PBS buffer PH7.5 |
Delivery condition | Blue ice (+4°C) |
Delivery Time | 3-5 days if in stock; 5-8 weeks if production needed |
Storage condition | 4°C for short term; -20°C for long term |
Brand | Proteogenix |
Applications | MS |
Aliases /Synonyms | REGN10933 |
Reference | PTXCOV-A552-SIL |
Related Products | This antibody targets the SARS-COV2 RBD domain for first type and variants referenced PX-COV-P046, PX-COV-P052, PX-COV-P053, PX-COV-P056. |
Note | For research use only. Not suitable for clinical or therapeutic use. |
Isotype | IgG1 |
Clonality | Monoclonal Antibody |
Format | Lyophilized |
Labelling | Arginine: 13C6,15N4 ; Lysine: 13C6,15N2 |
Isotopic Enrichment | 99% |
Stability | 1 year |
The receptor binding domain (RBD) of the SARS-CoV-2 spike protein is the most important target for the design of novel therapies for COVID-19. The development of antibodies that can target this specific area can be done in vivo, which is a time-consuming in vitro process or which can take advantage of the flexibility of visualization technologies such as pH age visualization. Anti-CoV-RBD antibody was developed by pHa to visualize the extensive library of COVID-19 (LiAb-SFCOVID-19 ) antibodies against SARS-CoV-2 RBD. Whereas generation of antibodies based on pH age does not require animal immunization or the use of immunogenic antigens, only small RBD proteins are used to isolate specific RBD ligands from the LiAb-SFCOVID-19 TM library. Furthermore, since the library is composed of immune libraries from COVID-19 patients, it possesses the largest and most important biological antibodies with important neutralizing activities.
Therefore, this specific antibody is a fully human immunoglobulin in IgG format. The ELISA (Enzyme-linked immunosorbent assay) test was used to test and verify its affinity for recombinantly expressed RBD. In addition, the neutralizing activity was tested by the SARS-CoV-2 Surrogate Virus Neutralization Test (sVNT), which is designed to rapidly assess the neutralization potential of new antibodies without using natural viral particles.
Finally, IgG antibodies are expressed in the XtenCHO high throughput mammalian transient system, exhibit very stable stability and consistently produce high yields.
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