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Product name | Stable Isotope Labelled Denosumab Biosimilar - Anti-RANKL mAb - Research Grade |
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Source | DrugBank DB06643 |
Species | Human |
Expression system | Mammalian cells |
Molecular weight | 144kDa |
Purity | >95% |
Buffer | PBS pH7.5 |
Delivery condition | Blue ice (+4°C) |
Delivery Time | 3-5 days if in stock; 5-8 weeks if production needed |
Storage condition | 4°C for short term; -20°C for long term |
Brand | ProteoGenix |
Applications | MS |
Aliases /Synonyms | Denosumab |
Reference | PX-TA1018-SIL |
Related Products | PX-P4774 |
Note | For research use only. Not suitable for clinical or therapeutic use. |
Isotype | IgG2Kappa |
Clonality | Monoclonal Antibody |
Format | Lyophilized |
Labelling | Arginine: 13C6,15N4 ; Lysine: 13C6,15N2, >99% |
Isotopic Enrichment | 99% |
Stability | 1 year |
Formula | C6404H9912N1724O2004S50 |
Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption markers in patients with a variety of metastatic tumors and is being investigated in multiple clinical trials for the prevention and treatment of bone metastases. Chemically, it consists of 2 heavy and 2 light chains. Each light chain consists of 215 amino acids. Each heavy chain consists of 448 amino acids with 4 intramolecular disulfides.This product is for research use only.
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