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Brand | |
Product type | |
Clonality | |
Expression system | |
Applications |
Product name | Adalimumab Biosimilar - Anti-TNF alpha mAb - Research Grade |
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Source | DrugBank DB00051 |
Species | Human |
Expression system | Mammalian |
Molecular weight | 144kDa |
Purity | >85% |
Buffer | PBS pH7.5 |
Delivery condition | Blue ice (+4°C) |
Delivery lead time in business days | 3-5 days if in stock; 3-5 weeks if production needed |
Delivery Time | 3-5 days if in stock; 3-5 weeks if production needed |
Storage condition | 4°C for short term; -20°C for long term |
Brand | ProteoGenix |
Applications | ELISA,WB |
Aliases /Synonyms | Adalimumab,Adalimumab,TNF alpha,anti-TNF alpha |
Reference | PX-TA1001 |
Note | For research use only. Not suitable for human use. |
Isotype | IgG1 |
Clonality | Monoclonal Antibody |
Adalimumab is a recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases.
Immobilized Human TNFa Recombinant Protein (cat. No. PX-P3058) at 0.5µg/mL (100µL/well) can bind Adalimumab Biosimilar - Anti-TNF alpha mAb (cat. No. PX-TA1001) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450 giving an EC50 at 142.1M.
Adalimumab Biosimilar - Anti-TNF alpha mAb, on SDS-PAGE under reducing and non-reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.
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Ofer Gover –
We used this ab to reduce as a negative control for reducing caco-2 (IEC) cells exitation by exugenues TNFa. We measured IL8 secreation as a result of TNFa stimulation. 1ug/mL ofAdalimumab Biosimilar – Anti-TNF alpha mAb was enough to completly abolish IL8 secreation by TNFa stimulation in caco-2 cells.