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View ProductsSize | 100ug, 50ug |
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Brand | |
Product type | |
Host Species | |
Applications |
Product name | CD19 Protein - Human CD19 recombinant protein |
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Uniprot ID | P15391 |
Uniprot link | http://www.uniprot.org/uniprot/P15391 |
Origin species | Homo sapiens (Human) |
Expression system | Eukaryotic expression |
Sequence | MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKENLYFQGSHHHHHH |
Molecular weight | 34.12kDa |
Protein delivered with Tag? | Yes |
Purity estimated | 80% |
Buffer | 150 mM NaCl, 50 mM Tris-HCl, pH 7.5 |
Form | Lyophilized |
Delivery condition | Dry Ice |
Delivery lead time in business days | 5-7 |
Storage condition | 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection) |
Brand | ProteoGenix |
Host species | Mammalian cells |
Applications | ELISA,WB |
Fragment Type | Partial |
Aliases /Synonyms | B-lymphocyte antigen CD19, CD19 |
Reference | PX-P4004 |
Note | For research use only |
CD19 protein also known as B-lymphocyte antigen CD19, T-cell Surface Antigen LEU-12 and CDID3 is a type I transmembrane protein coded by the gene CD19 in humans. The protein consists of a single transmembrane domain with a cytoplasmic C-terminus and an extracellular N-terminus. CD19 protein is expressed in B cell lineage but not expressed in plasma cells. This protein is also present in follicular dendritic cells. As such CD19 protein can be used a biomarker for B lymphocyte development and follicular dendritic cells. CD19 protein plays a critical role in maintaining the balance between humoral, antigen-induced response and tolerance induction.
CD19 protein acts as coreceptor for the B-cell antigen receptor complex (BCR) and functions as an adaptor protein for the recruitment of cytoplasmic signals. It decreases the threshold for activation of downstream signaling pathways involved in B-cell responses to antigens. CD protein activates signaling pathways responsible fot the activation of phosphatidylinositol 3-kinase. The latter is responsible for the mobilization of intracellular Ca2+ stores. CD19 protein is not required for early steps of B cell differentiation in the blood marrow. However, CD19 protein is required for normal B-Cell differentiation and B-cell proliferation in response to antigen challenges. This protein is also needed in the production of normal levels of high-affinity antibodies and for normal levels of serum immunoglobulins.
CD19 protein interacts with several proteins and protein complexes such as CD81 and CR2/CD21. The direct interaction of CD protein with CD81 (via the second extracellular domain) is essential for the trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells. CD19 protein, along with CR2/CD21, CD81 and IFITM1/CD225, is part of a complex in the membrane of mature B-cells. Other CD19 protein interactions include GRB2 and SOS (when phosphorylated on Tyr-348 and/or Tyr-378), PLCG2 (when phosphorylated on Tyr-409), LYN and the regulatory p85 subunit of phosphatidylinositol 3-kinase.
CD19 Protein - Human CD19 recombinant protein, on SDS-PAGE under non-reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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