Name: Mouse PAD4 protein-arginine deiminase type-4 Recombinant Protein
SKU: PX-P4068-10
Availability: InStock

Size	100ug, 50ug
Brand	ProteoGenix
Product type	Recombinant Proteins
Host Species	Insect
Applications	Elisa, WB

Cancer Immunology

Product name	Mouse PAD4 protein-arginine deiminase type-4 Recombinant Protein
Uniprot ID	Q9Z183
Uniprot link	https://www.uniprot.org/uniprot/Q9Z183
Origin species	House Mouse
Expression system	Eukaryotic expression
Sequence	MGASWSHPQFEKGGGSGGGSGGSAWSHPQFEKMAQGAVIHVAPEQPTHAVCVVGTATPLDVRGSAPKGYTTFGITASPGVIVDVIHGPPVKKSTMGASKWPLDPELEVTLQVKAASSRTDDEKVRVSYYGPKTSPVQALIYITGVELSLSADVTRTGRVKPAQAGKDQSTWTWGPGGRGAILLVNCDKEDPQASGMDFEDDKILDNKDLQDMSPMTLSTKTPKDFFEKYQLVLEVPKAKMNRVRVFRATRGKLPSRYKVALGPQQFSYCLELPGGQHSTDFYVEGLAFPDADFKGLIPLTISLLDKSNPELPEALVFQDSVTFRVAPWIMTPNTQPPQEVYVCRVSDNEDFLKSLATLTKKAKCKLTVCPEEENIDDQWMQDEMEIGYIQAPHKTLPVVFDSPRDRGLKDFPVKRVMGPNFGYVTRKLYMSELTGLDAFGNLEVSPPVTVRGKEYPLGRILIGNSGYSSSESRDMHQALQDFLSAQQVQAPVRLFSDWLFVGHVDEFLSFVPARDKQGFRLLLSSPRACYQLFQELQSQGHGEATLFEGLKRKRQTINEILSNKKLRDQNAYVESCIDWNRAVLKRELGLAEGDIIDIPQLFKLAGNSRGNSKAQAFFPNMVNMLVLGKYLGIPKPFGPIIDGHCCLEEEVRSHLEPLGLHCTFINDFYTYHVYNGEVHCGTNVRRKPFTFKWWHMVP
Molecular weight	77.52kDa
Protein delivered with Tag?	Yes
Purity estimated	90%
Buffer	50mM Tris-Cl pH 8.0, 150mM NaCl
Form	Frozen
Delivery condition	Dry Ice
Delivery lead time in business days	10-25
Storage condition	4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand	ProteoGenix
Host species	Insect
Applications	ELISA,WB
Fragment Type	Full-length
Protein Accession	NP_035191.2
Spec:Entrez GeneID	18602
Spec:NCBI Gene Aliases	Pad4, Pdi4，Padi4
Spec:SwissProtID	Q9Z183
NCBI Reference	NP_035191.2
Aliases /Synonyms	Pad4, Pdi4，Padi4，Peptidylarginine deiminase IV,Protein-arginine deiminase type IV
Reference	PX-P4068
Note	For research use only

Description of Mouse PAD4 protein-arginine deiminase type-4 Recombinant Protein

General Information nn Mouse PAD4 :

Mouse PAD4 (PADI4) functions as a transcriptional coregulator by catalyzing the conversion of histone H3 arginine residues to citrulline residues. This reaction, known as citrullination, leads to the post-translational modification of proteins.

PADI4 gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. PAD4 is mainly expressed in granulocytes, monocytes and CD34+ stem cells. Protein arginine deiminase type-4 was initially cloned from the HL-60 cell line (human promyelocytic leukemia cells). Protein arginine deiminase type-4 may play a role in granulocyte and macrophage development leading to inflammation and immune response. The PADI4 single-nucleotide polymorphism (SNP) and haplotypes were associated with rheumatoid arthritis susceptibility.
Recently, PAD4 has also been found in a variety of malignant tumors and implies its potential roles in tumor genesis.

Eukaryote expression systems and more specifically Insect cells are used at ProteoGenix to produce mouse PAD4 recombinant protein with appropriate post translational modifications.

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MSDS Download

Publication

1. F. Arnoux and al (2017).
Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types.

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