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ProteoGenix
Recombinant Proteins
Insect
Elisa, WB
PADI4 gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. PAD4 is mainly expressed in granulocytes, monocytes and CD34+ stem cells. Protein arginine deiminase type-4 was initially cloned from the HL-60 cell line (human promyelocytic leukemia cells). Protein arginine deiminase type-4 may play a role in granulocyte and macrophage development leading to inflammation and immune response. The PADI4 single-nucleotide polymorphism (SNP) and haplotypes were associated with rheumatoid arthritis susceptibility. Recently, PAD4 has also been found in a variety of malignant tumors and implies its potential roles in tumor genesis.
Eukaryote expression systems and more specifically Insect cells are used at ProteoGenix to produce mouse PAD4 recombinant protein with appropriate post translational modifications.
Publication
1. F. Arnoux and al (2017).Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types.
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