Recombinant Human AASDHPPT, N-His

Description of Recombinant Human AASDHPPT, N-His

Title: Introduction to Recombinant Human AASDHPPT

Recombinant Human AASDHPPT, also known as Alanyl-tRNA synthetase domain-containing protein 2 (AASDHPPT), is a recombinant protein that plays a crucial role in protein synthesis. This protein is involved in the process of attaching alanine to transfer RNA (tRNA) molecules, which is essential for the production of functional proteins in the body. In this article, we will explore the structure, activity, and applications of Recombinant Human AASDHPPT.

Title: Structure of Recombinant Human AASDHPPT

Recombinant Human AASDHPPT is a 106 kDa protein that consists of 947 amino acids. It is composed of multiple domains, including an N-terminal catalytic domain, a middle domain, and a C-terminal anticodon-binding domain. The N-terminal domain is responsible for the catalytic activity of the protein, while the middle domain plays a role in tRNA recognition. The C-terminal domain binds to the anticodon loop of tRNA, ensuring the accurate attachment of alanine to the tRNA molecule.

Title: Activity of Recombinant Human AASDHPPT

The primary function of Recombinant Human AASDHPPT is to attach alanine to tRNA molecules, which is a critical step in protein synthesis. This process, also known as aminoacylation, is essential for the production of functional proteins in the body. AASDHPPT specifically attaches alanine to tRNA molecules with the anticodon sequence GCU, which is the specific sequence required for alanine incorporation into proteins.

Title: Applications of Recombinant Human AASDHPPT

1. Antibody Production: Recombinant Human AASDHPPT is widely used in antibody production as an antigen for immunization. Antibodies produced against AASDHPPT can be used for various research and diagnostic purposes, such as detecting the presence of AASDHPPT in different tissues or studying its role in various diseases.

2. Drug Development: AASDHPPT has been identified as a potential target for drug development due to its crucial role in protein synthesis. Inhibitors of AASDHPPT could potentially be used to treat diseases caused by abnormal protein synthesis, such as cancer and neurodegenerative disorders.

3. Gene Therapy: Recombinant Human AASDHPPT can also be used in gene therapy to treat genetic disorders caused by mutations in the AASDHPPT gene. By introducing a functional copy of the gene, the production of functional AASDHPPT can be restored, leading to the correction of the underlying genetic defect.

4. Protein Production: AASDHPPT is also used in the production of recombinant proteins. By attaching alanine to tRNA molecules, AASDHPPT ensures the accurate incorporation of alanine into the growing protein chain, resulting in the production of functional proteins.

Title: Conclusion

In conclusion, Recombinant Human AASDHPPT is a crucial protein involved in protein synthesis. Its structure and activity allow for the accurate attachment of alanine to tRNA molecules, which is essential for the production of functional proteins. AASDHPPT has various applications in research, drug development, gene therapy, and protein production, making it a valuable tool in the scientific community. Further research on AASDHPPT could lead to a better understanding of its role in health and disease, potentially leading to the development of new therapeutic strategies.