Recombinant Human ADCY6 Protein, N-His

Description of Recombinant Human ADCY6 Protein, N-His

Recombinant Human ADCY6 Protein: Structure, Activity, and Application

Introduction

Recombinant proteins are proteins that are produced through genetic engineering techniques, where the gene encoding the protein of interest is inserted into a host cell and expressed to produce the desired protein. Recombinant proteins have become an essential tool in many fields of biotechnology and medicine, including drug discovery and development, diagnostics, and basic research.

Structure of Recombinant Human ADCY6 Protein

The recombinant human ADCY6 protein is a member of the adenylate cyclase family, which is responsible for the conversion of ATP to cyclic AMP (cAMP). This protein is encoded by the ADCY6 gene located on chromosome 12 in humans. The protein is composed of 1217 amino acids with a molecular weight of approximately 136 kDa. It contains two transmembrane domains, six intracellular domains, and two extracellular domains.

Activity of Recombinant Human ADCY6 Protein

The main function of ADCY6 is to catalyze the conversion of ATP to cAMP, which is an important second messenger in many signaling pathways. This protein is primarily expressed in the brain, heart, and skeletal muscle, and plays a crucial role in regulating cardiac contractility, smooth muscle relaxation, and neurotransmitter release. Mutations in the ADCY6 gene have been associated with various diseases, including heart failure, hypertension, and obesity.

Application of Recombinant Human ADCY6 Protein

Recombinant human ADCY6 protein has various applications in both research and clinical settings. One of the main applications is in drug discovery and development. As ADCY6 plays a significant role in various signaling pathways, it is a potential target for drug development in diseases such as heart failure and hypertension. Recombinant ADCY6 protein can be used in high-throughput screening assays to identify potential drug candidates that can modulate its activity.

Another application of recombinant ADCY6 protein is in diagnostics. As mentioned earlier, mutations in the ADCY6 gene have been linked to various diseases. Therefore, detection of these mutations can aid in the early diagnosis and treatment of these diseases. Recombinant ADCY6 protein can be used in diagnostic tests to detect these mutations and provide valuable information for personalized treatment.

Furthermore, recombinant ADCY6 protein can also be used in basic research to study its structure, function, and regulation. By producing this protein in large quantities, researchers can perform biochemical and biophysical studies to gain a better understanding of its role in various biological processes. This knowledge can then be applied to develop new therapies for diseases associated with ADCY6 dysfunction.

Conclusion

In conclusion, recombinant human ADCY6 protein is an essential tool in biotechnology and medicine. Its structure and activity have been extensively studied, and it has various applications in drug discovery, diagnostics, and basic research. As more research is conducted on this protein, its potential in the development of new therapies for diseases will continue to grow, making it a valuable asset in the scientific community.