Recombinant Human CD171/L1CAM Protein, N-His

Description of Recombinant Human CD171/L1CAM Protein, N-His

Introduction

Recombinant Human CD171/L1CAM Protein, also known as L1 cell adhesion molecule (L1CAM), is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is encoded by the L1CAM gene and is expressed in many tissues and cell types, including the nervous system, kidney, and muscle cells. This protein plays a crucial role in cell adhesion, migration, and axon guidance during development.

Structure of Recombinant Human CD171/L1CAM Protein

The structure of Recombinant Human CD171/L1CAM Protein consists of six immunoglobulin-like domains (Ig-like domains), five fibronectin type III (FNIII) repeats, and a transmembrane domain. The Ig-like domains are responsible for cell adhesion and are involved in protein-protein interactions. The FNIII repeats are involved in homophilic binding, which allows the protein to bind to other L1CAM molecules on the surface of adjacent cells. The transmembrane domain anchors the protein to the cell membrane.

Activity of Recombinant Human CD171/L1CAM Protein

Recombinant Human CD171/L1CAM Protein is a cell adhesion molecule that is involved in a variety of cellular processes. It plays a crucial role in neuronal development, including axon guidance, neurite outgrowth, and synapse formation. It is also involved in the migration and differentiation of neural crest cells during embryonic development. In addition, this protein is involved in the maintenance and regeneration of the nervous system in adults.

One of the key activities of Recombinant Human CD171/L1CAM Protein is its role in cell adhesion. It mediates cell-cell interactions by binding to other L1CAM molecules or other cell adhesion molecules, such as integrins and cadherins. This allows cells to adhere to one another and form stable connections, which is essential for proper cell migration and tissue formation.

Another important activity of Recombinant Human CD171/L1CAM Protein is its involvement in axon guidance. During development, axons extend from neurons and navigate through complex environments to reach their target destinations. L1CAM is expressed on the surface of axons and acts as a guidance cue, helping axons to navigate to their correct targets. This is achieved through interactions with other L1CAM molecules or with extracellular matrix components.

Application of Recombinant Human CD171/L1CAM Protein

Recombinant Human CD171/L1CAM Protein has a wide range of applications in both research and clinical settings. In research, this protein is commonly used as a tool to study cell adhesion, axon guidance, and other cellular processes. It can be used in cell culture studies, as well as in animal models, to investigate the role of L1CAM in various biological processes.

In clinical settings, Recombinant Human CD171/L1CAM Protein has potential therapeutic applications. It has been shown to play a role in various diseases and disorders, including cancer, developmental disorders, and neurological diseases. Targeting L1CAM with specific antibodies or small molecule inhibitors has been explored as a potential treatment strategy for these conditions.

One specific application of Recombinant Human CD171/L1CAM Protein is in the treatment of neurodegenerative diseases. It has been shown to promote neuronal survival and regeneration, making it a potential therapeutic target for conditions such as Alzheimer’s disease and Parkinson’s disease.

Conclusion

Recombinant Human CD171/L1CAM Protein is a transmembrane glycoprotein that plays a crucial role in cell adhesion, axon guidance, and other cellular processes. Its structure, activity, and applications make it a valuable tool for research and a potential therapeutic target for various diseases. Further studies on this protein will continue to provide insights into its role in development and disease, and potentially lead to the development of new treatments for various conditions.