Recombinant Human CHCHD10 Protein, N-GST & C-His

Description of Recombinant Human CHCHD10 Protein, N-GST & C-His

Introduction

Recombinant Human CHCHD10 Protein, also known as coiled-coil-helix-coiled-coil-helix domain-containing protein 10, is a highly conserved protein that is encoded by the CHCHD10 gene. This protein is a member of the CHCHD family, which is a group of proteins that contain a coiled-coil-helix-coiled-coil-helix domain. CHCHD10 is a mitochondrial protein that is involved in various cellular processes, including mitochondrial metabolism, oxidative stress response, and apoptosis. In this article, we will discuss the structure, activity, and application of Recombinant Human CHCHD10 Protein.

Structure of Recombinant Human CHCHD10 Protein

The Recombinant Human CHCHD10 Protein is a 141-amino acid protein with a molecular weight of approximately 16 kDa. It contains a highly conserved coiled-coil-helix-coiled-coil-helix domain at the N-terminus and a C-terminal extension. The coiled-coil-helix-coiled-coil-helix domain is responsible for protein-protein interactions and is essential for the function of CHCHD10. The C-terminal extension contains a hydrophobic region that is responsible for targeting the protein to the mitochondria.

Activity of Recombinant Human CHCHD10 Protein

Recombinant Human CHCHD10 Protein is involved in various cellular processes, including mitochondrial metabolism, oxidative stress response, and apoptosis. It is mainly localized in the mitochondrial intermembrane space, where it interacts with other proteins to regulate mitochondrial function. CHCHD10 has been shown to play a role in maintaining mitochondrial membrane potential, regulating mitochondrial respiration, and controlling the production of reactive oxygen species (ROS).

One of the key activities of CHCHD10 is its role in mitochondrial metabolism. It interacts with other mitochondrial proteins, such as cytochrome c oxidase, to regulate the production of ATP, the main source of energy for the cell. CHCHD10 also plays a role in the regulation of mitochondrial respiration, which is essential for the production of ATP. Studies have shown that CHCHD10 deficiency leads to impaired mitochondrial respiration and decreased ATP production, which can have detrimental effects on cellular function.

In addition to its role in mitochondrial metabolism, Recombinant Human CHCHD10 Protein is also involved in the cellular response to oxidative stress. It has been shown to protect cells from oxidative damage by regulating the production of ROS. CHCHD10 interacts with other proteins, such as glutathione peroxidase, to scavenge ROS and prevent oxidative damage to the mitochondria.

Furthermore, CHCHD10 has been found to play a role in apoptosis, the process of programmed cell death. It has been shown to interact with Bax, a pro-apoptotic protein, and prevent its translocation to the mitochondria, thus inhibiting apoptosis. This activity of CHCHD10 is essential for maintaining cellular homeostasis and preventing cell death.

Application of Recombinant Human CHCHD10 Protein

Recombinant Human CHCHD10 Protein has a wide range of applications in both research and therapeutic settings. Its involvement in mitochondrial metabolism and oxidative stress response makes it a valuable tool for studying mitochondrial function and dysfunction. Researchers can use Recombinant Human CHCHD10 Protein to study the role of this protein in various cellular processes, including mitochondrial metabolism, oxidative stress response, and apoptosis.

In therapeutic applications, Recombinant Human CHCHD10 Protein has shown potential for the treatment of various diseases. Studies have shown that mutations in the CHCHD10 gene are associated with neurodegenerative diseases, such as Parkinson’s disease and amyotrophic lateral sclerosis (ALS). Recombinant Human CHCHD10 Protein can be used to study the effects of these mutations and develop potential therapeutic strategies to treat these diseases.

In conclusion, Recombinant Human CHCHD10 Protein is a highly conserved mitochondrial protein that plays a crucial role in various cellular processes. Its