Recombinant Human CHGA Protein, N-His

Description of Recombinant Human CHGA Protein, N-His

Introduction

The Recombinant Human CHGA Protein is a synthetic form of the human chromogranin A (CHGA) protein, which is a member of the granin family of proteins. CHGA is primarily found in neuroendocrine cells and is involved in the storage and secretion of hormones and neuropeptides. Recombinant CHGA protein is produced through genetic engineering techniques, making it a valuable tool for research and therapeutic applications.

Structure of Recombinant Human CHGA Protein

The recombinant CHGA protein is a polypeptide chain consisting of 439 amino acids with a molecular weight of approximately 49 kDa. It shares a high degree of sequence homology with the native human CHGA protein, ensuring its functional similarity. The protein contains several domains, including a signal peptide, a propeptide region, and a mature region, which is responsible for its biological activity.

Activity of Recombinant Human CHGA Protein

The primary function of CHGA protein is to regulate the storage and release of hormones and neuropeptides in neuroendocrine cells. It is also involved in the formation and maintenance of secretory granules, which are responsible for the storage and secretion of these molecules. Recombinant CHGA protein has been shown to exhibit similar activity to the native protein, making it a useful tool for studying the role of CHGA in various biological processes.

Studies have also shown that CHGA protein has antimicrobial properties, making it an important component of the innate immune system. Recombinant CHGA protein has been found to have similar antimicrobial activity, making it a potential therapeutic agent for treating infections caused by bacteria, viruses, and fungi.

Application of Recombinant Human CHGA Protein

The recombinant CHGA protein has a wide range of applications in both research and therapeutics. Some of the major applications include:

1. Research

Recombinant CHGA protein is a valuable tool for studying the role of CHGA in various biological processes. It can be used to investigate the mechanisms of hormone and neuropeptide storage and secretion, as well as the formation and function of secretory granules. It can also be used to study the antimicrobial properties of CHGA and its potential role in the immune system.

2. Diagnostics

CHGA protein has been identified as a potential biomarker for various diseases, including neuroendocrine tumors, cardiovascular diseases, and inflammatory disorders. Recombinant CHGA protein can be used in diagnostic tests to measure the levels of CHGA in patient samples, providing valuable information for disease diagnosis and monitoring.

3. Therapeutics

Recombinant CHGA protein has shown promising results in preclinical studies as a potential therapeutic agent for various diseases. Its antimicrobial properties make it a potential treatment for infections, while its role in hormone and neuropeptide regulation makes it a potential treatment for neuroendocrine disorders. It can also be used as a drug delivery system for targeted delivery of therapeutic molecules to neuroendocrine cells.

4. Vaccine Development

CHGA protein has been identified as a potential antigen for vaccine development against bacterial and viral infections. Recombinant CHGA protein can be used to develop vaccines that can stimulate the immune system to produce antibodies against CHGA, providing protection against these pathogens.

5. Cosmetic Applications

CHGA protein has been found to have anti-aging properties, making it a potential ingredient in cosmetic products. Recombinant CHGA protein can be used in the development of anti-aging creams and serums, providing a natural and effective alternative to synthetic ingredients.

Conclusion

The Recombinant Human CHGA Protein is a valuable tool for studying the role of CHGA in various biological processes and has a wide range of applications in research and