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AntibodySystem
Recombinant Proteins
Recombinant Human CLDN18/Claudin-18 Protein, also known as CLDN18.1, is a transmembrane protein that belongs to the Claudin family. Claudins are a group of tight junction proteins that play a crucial role in maintaining the integrity of epithelial and endothelial cell layers. CLDN18 is specifically expressed in the stomach, where it forms tight junctions between epithelial cells and helps to regulate the permeability of the gastric mucosa.
The recombinant form of CLDN18 is produced through genetic engineering techniques, where the gene encoding for CLDN18 is inserted into a suitable expression vector and expressed in a host cell. The resulting protein is a 24 kDa transmembrane protein with four transmembrane domains, two extracellular loops, and a short cytoplasmic tail. The extracellular loops contain conserved sequences that are important for the formation of tight junctions, while the cytoplasmic tail is involved in signaling and regulation of tight junction function.
CLDN18 plays a crucial role in maintaining the integrity of the gastric mucosa and regulating the permeability of the stomach. It does this by forming tight junctions between epithelial cells, which act as a barrier to prevent the passage of harmful substances from the stomach lumen into the underlying tissues. CLDN18 also helps to regulate the movement of ions and water across the epithelial layer, maintaining the proper balance of fluids in the stomach.
In addition to its role in maintaining the integrity of the stomach, CLDN18 has also been found to play a role in the development and progression of certain cancers, particularly gastric cancer. Studies have shown that CLDN18 is overexpressed in gastric cancer cells and is associated with a poor prognosis. This makes CLDN18 a potential target for cancer therapy, and recombinant CLDN18 protein can be used in research to better understand its role in cancer development and to develop targeted treatments.
The use of recombinant CLDN18 protein has various applications in both research and medical fields. In research, it can be used to study the structure and function of tight junctions and their role in maintaining the integrity of epithelial and endothelial cell layers. It can also be used in cancer research to study the role of CLDN18 in cancer development and to develop targeted therapies.
In the medical field, recombinant CLDN18 protein has potential applications in the treatment of gastric cancer. As mentioned earlier, CLDN18 is overexpressed in gastric cancer cells, and targeting this protein could potentially inhibit the growth and spread of cancer cells. Recombinant CLDN18 protein can also be used in diagnostic tests for gastric cancer, as its overexpression can serve as a biomarker for the disease.
In summary, Recombinant Human CLDN18/Claudin-18 Protein is a transmembrane protein that plays a crucial role in maintaining the integrity of the gastric mucosa and regulating the permeability of the stomach. Its recombinant form is produced through genetic engineering techniques and has various applications in research and medicine. Further studies on this protein could lead to a better understanding of its role in cancer development and potentially new treatments for gastric cancer.
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