Recombinant Human CNR1/CB1 Protein, N-GST & C-His

Description of Recombinant Human CNR1/CB1 Protein, N-GST & C-His

Introduction

Recombinant Human CNR1/CB1 Protein, also known as Cannabinoid Receptor 1 (CB1), is a protein that plays a crucial role in the endocannabinoid system. This system is responsible for regulating various physiological processes such as pain, appetite, and mood. The CB1 protein is a G protein-coupled receptor (GPCR) that is activated by the endocannabinoid neurotransmitter, anandamide. This protein has been extensively studied and its structure, activity, and applications have been well characterized.

Structure of Recombinant Human CNR1/CB1 Protein

The CB1 protein is a transmembrane protein consisting of 472 amino acids. It is encoded by the CNR1 gene located on chromosome 6 in humans. The protein is composed of seven transmembrane helices connected by three extracellular and three intracellular loops. The extracellular loops are responsible for ligand binding, while the intracellular loops interact with G proteins and other signaling molecules.

Activity of Recombinant Human CNR1/CB1 Protein

The CB1 protein is primarily expressed in the central nervous system, particularly in the brain, where it is involved in various physiological processes. Upon activation by anandamide, the CB1 protein undergoes a conformational change, leading to the activation of downstream signaling pathways. This results in the modulation of neurotransmitter release, leading to the regulation of pain, appetite, and mood.

The CB1 protein is also expressed in peripheral tissues, such as the immune system, where it plays a role in regulating immune responses. Studies have shown that activation of CB1 receptors can reduce inflammation and modulate immune cell function. This makes the CB1 protein a potential target for the treatment of inflammatory diseases.

Applications of Recombinant Human CNR1/CB1 Protein

Recombinant Human CNR1/CB1 Protein has various applications in both research and therapeutics. In research, this protein is used as an antigen for the production of specific antibodies. These antibodies can be used to study the expression and localization of CB1 receptors in different tissues and cell types.

In therapeutics, the CB1 protein has been a target for the development of drugs for the treatment of various conditions. For example, CB1 receptor agonists have been used to stimulate appetite in patients with HIV/AIDS and cancer. On the other hand, CB1 receptor antagonists have been studied for their potential in the treatment of obesity and addiction.

Additionally, the CB1 protein has been studied for its potential in the treatment of neurological disorders, such as epilepsy and multiple sclerosis. Studies have shown that activation of CB1 receptors can reduce seizures and improve symptoms in patients with these conditions.

Conclusion

In summary, Recombinant Human CNR1/CB1 Protein is a crucial component of the endocannabinoid system, playing a role in regulating various physiological processes. Its structure, activity, and applications have been extensively studied, making it a valuable tool in both research and therapeutics. Further research on this protein may lead to the development of new treatments for various diseases and conditions.