Recombinant Human CXCL5/ENA-78 Protein, N-His-SUMO

Description of Recombinant Human CXCL5/ENA-78 Protein, N-His-SUMO

Introduction

Recombinant Human CXCL5/ENA-78 Protein, also known as epithelial cell-derived neutrophil-activating peptide 78 (ENA-78), is a chemokine protein that plays a crucial role in the immune system. This protein is produced through recombinant DNA technology, making it a valuable tool in various scientific research and applications. In this article, we will discuss the structure, activity, and applications of Recombinant Human CXCL5/ENA-78 Protein.

Structure of Recombinant Human CXCL5/ENA-78 Protein

Recombinant Human CXCL5/ENA-78 Protein is a small protein consisting of 78 amino acids with a molecular weight of approximately 8.7 kDa. It belongs to the CXC chemokine family and is primarily produced by epithelial cells in response to inflammatory stimuli. The protein has a conserved structure with a highly conserved N-terminal region and a less conserved C-terminal region. The N-terminal region contains four cysteine residues that form two disulfide bonds, which are essential for the protein’s stability and activity.

Activity of Recombinant Human CXCL5/ENA-78 Protein

Recombinant Human CXCL5/ENA-78 Protein is a potent chemoattractant for neutrophils, a type of white blood cell that plays a crucial role in the body’s immune response. It binds to the CXCR2 receptor on the surface of neutrophils, inducing their migration towards the site of inflammation. This protein also has pro-inflammatory properties, as it can stimulate the production of other inflammatory cytokines and chemokines. Additionally, Recombinant Human CXCL5/ENA-78 Protein can enhance the adhesion of neutrophils to endothelial cells, promoting their recruitment to the site of injury or infection.

Applications of Recombinant Human CXCL5/ENA-78 Protein

Due to its potent activity and role in the immune system, Recombinant Human CXCL5/ENA-78 Protein has various applications in scientific research. Here are some of its most common applications:

1. Study of Inflammation and Immune Response

Recombinant Human CXCL5/ENA-78 Protein is widely used in the study of inflammation and immune response. Its ability to recruit neutrophils and stimulate the production of other inflammatory molecules makes it a valuable tool in understanding the mechanisms of inflammation and immune system regulation. This protein can also be used to investigate the role of specific chemokines and cytokines in various diseases and conditions.

2. Drug Development

The pro-inflammatory properties of Recombinant Human CXCL5/ENA-78 Protein make it a potential target for drug development. By blocking its activity, it may be possible to reduce the severity of inflammatory diseases such as rheumatoid arthritis, asthma, and inflammatory bowel disease. On the other hand, enhancing its activity may be beneficial in certain conditions, such as wound healing and tissue repair.

3. Diagnostic Tool

Recombinant Human CXCL5/ENA-78 Protein can also be used as a diagnostic tool for various diseases. Elevated levels of this protein have been observed in patients with inflammatory conditions, making it a potential biomarker for disease diagnosis and monitoring. Furthermore, measuring the levels of this protein in bodily fluids, such as blood or urine, can provide valuable information about the extent and severity of inflammation in the body.

4. Vaccine Development

Recombinant Human CXCL5/ENA-78 Protein has also been investigated as a potential antigen for vaccine development. By incorporating this protein into a vaccine, it may be possible to induce a specific immune response against it, providing protection against infections and diseases that involve this protein.

Conclusion

In summary, Recombinant Human CXCL5/ENA-78 Protein is a small but powerful chemokine with various applications in scientific research. Its structure