Recombinant Human ELP3 Protein, N-His

Description of Recombinant Human ELP3 Protein, N-His

Structure of Recombinant Human ELP3 Protein

Recombinant Human ELP3 Protein, also known as Elongator complex protein 3, is a highly conserved protein that is found in all eukaryotic organisms. It is encoded by the ELP3 gene and is composed of 808 amino acids, with a molecular weight of approximately 93 kDa.

The protein has a complex structure, consisting of several domains that play important roles in its function. These domains include the N-terminal domain, the central domain, the C-terminal domain, and the histone acetyltransferase (HAT) domain.

The N-terminal domain of Recombinant Human ELP3 Protein is responsible for its interaction with other components of the Elongator complex, while the central domain is involved in its binding to RNA. The C-terminal domain is important for its association with the microtubule network, and the HAT domain is responsible for its acetyltransferase activity.

Activity of Recombinant Human ELP3 Protein

Recombinant Human ELP3 Protein plays a crucial role in various cellular processes, including transcription, translation, and DNA repair. It is a subunit of the Elongator complex, which is involved in the elongation of RNA polymerase II transcripts. This elongation process is essential for the proper transcription of genes and is regulated by the activity of Recombinant Human ELP3 Protein.

In addition, Recombinant Human ELP3 Protein has been shown to have histone acetyltransferase (HAT) activity, which is important for the modification of histones and the regulation of gene expression. This activity is crucial for chromatin remodeling and DNA repair, as well as for the maintenance of genomic stability.

Moreover, Recombinant Human ELP3 Protein has been found to interact with various proteins involved in neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. This suggests a potential role for Recombinant Human ELP3 Protein in the pathogenesis of these diseases.

Application of Recombinant Human ELP3 Protein

The unique structure and activity of Recombinant Human ELP3 Protein make it a valuable tool for various applications in the field of biotechnology and medicine. One of the main applications of this protein is in the production of recombinant proteins.

Recombinant Human ELP3 Protein can be used as a fusion partner for the expression of other proteins, allowing for their purification and characterization. Its HAT domain can also be utilized for the acetylation of recombinant proteins, which can improve their stability and activity.

Furthermore, Recombinant Human ELP3 Protein has potential applications in the treatment of neurodegenerative diseases. Its interaction with disease-associated proteins suggests a possible role in the development of therapeutic strategies for these conditions.

Additionally, Recombinant Human ELP3 Protein has been studied in the context of cancer research. Its involvement in DNA repair and chromatin remodeling processes makes it a potential target for cancer therapy.

Conclusion

In summary, Recombinant Human ELP3 Protein is a highly conserved protein with a complex structure and diverse activities. Its role in transcription, translation, and DNA repair makes it a crucial component of cellular processes. Its unique structure and activity also make it a valuable tool for various applications in biotechnology and medicine, including the production of recombinant proteins and potential therapeutic interventions for neurodegenerative diseases and cancer.