Recombinant Human FDFT1 Protein, N-His-SUMO

Description of Recombinant Human FDFT1 Protein, N-His-SUMO

Introduction to Recombinant Human FDFT1 Protein

Recombinant proteins are proteins that are produced through genetic engineering techniques, where the DNA sequence of a gene is inserted into a host organism to produce a specific protein. One such recombinant protein is the Recombinant Human FDFT1 Protein, which plays an important role in cholesterol biosynthesis.

Structure of Recombinant Human FDFT1 Protein

The FDFT1 gene encodes for the enzyme squalene synthase, which is responsible for the conversion of farnesyl pyrophosphate (FPP) to squalene in the cholesterol biosynthesis pathway. The Recombinant Human FDFT1 Protein is a 54 kDa protein consisting of 471 amino acids. It has a highly conserved N-terminal domain, which is responsible for the catalytic activity of the enzyme, and a C-terminal domain, which is involved in the regulation of the enzyme.

Activity of Recombinant Human FDFT1 Protein

The main function of the Recombinant Human FDFT1 Protein is to catalyze the conversion of FPP to squalene in the cholesterol biosynthesis pathway. This reaction is the first committed step in the synthesis of cholesterol, which is an essential component of cell membranes and plays a critical role in various physiological processes. The enzyme achieves this by condensing two molecules of FPP to form squalene, which is then further converted to cholesterol.

In addition to its role in cholesterol biosynthesis, the Recombinant Human FDFT1 Protein has been found to have other important functions. Studies have shown that this protein is also involved in the regulation of cell proliferation, differentiation, and apoptosis. It has been reported that FDFT1 expression is upregulated in various types of cancer, suggesting a potential role of this protein in cancer development and progression.

Application of Recombinant Human FDFT1 Protein

The Recombinant Human FDFT1 Protein has various applications in both research and industrial settings. One of the main applications of this protein is in the study of cholesterol biosynthesis and its regulation. By using recombinant FDFT1 protein, researchers can investigate the role of this enzyme in various physiological processes and diseases, such as hypercholesterolemia and cancer.

In the pharmaceutical industry, the Recombinant Human FDFT1 Protein is used in the development of drugs targeting cholesterol biosynthesis. Inhibitors of this enzyme have been developed as potential treatments for hypercholesterolemia and other cholesterol-related disorders. By using recombinant FDFT1 protein, researchers can screen and identify potential drug candidates, as well as study the mechanism of action of these inhibitors.

Furthermore, the Recombinant Human FDFT1 Protein has also been used in the production of cholesterol and other sterols in the food and cosmetic industries. This enzyme is used in the synthesis of plant sterols, which are added to foods as cholesterol-lowering agents. It is also used in the production of phytosterols, which are used in cosmetic products for their anti-inflammatory and antioxidant properties.

Conclusion

In summary, the Recombinant Human FDFT1 Protein is a crucial enzyme in cholesterol biosynthesis and has various important functions in cellular processes. Its structure and activity have been extensively studied, and its potential applications in research and industry make it a valuable protein for scientific studies. With the continued advancements in genetic engineering techniques, the production and use of recombinant proteins, such as the Recombinant Human FDFT1 Protein, will continue to contribute to our understanding of biological processes and the development of new therapies.