Recombinant Human FSHR Protein, N-His

Description of Recombinant Human FSHR Protein, N-His

Introduction to Recombinant Human FSHR Protein

Recombinant Human FSHR Protein, also known as Follicle-Stimulating Hormone Receptor, is a protein that plays a crucial role in the reproductive system. It is a G-protein coupled receptor that is expressed on the surface of ovarian granulosa cells and testicular Sertoli cells. This protein is responsible for binding to follicle-stimulating hormone (FSH) and initiating a cascade of events that lead to the production of estrogen and sperm development. In this article, we will discuss the structure, activity, and applications of Recombinant Human FSHR Protein.

Structure of Recombinant Human FSHR Protein

The gene for Recombinant Human FSHR Protein is located on chromosome 2 and is composed of 11 exons. The protein is made up of 695 amino acids and has a molecular weight of approximately 80 kDa. It consists of a large extracellular domain, seven transmembrane domains, and an intracellular domain. The extracellular domain contains the binding site for FSH, while the intracellular domain is responsible for activating the G-protein signaling pathway.

Recombinant Human FSHR Protein is produced through recombinant DNA technology, where the gene for FSHR is inserted into a host cell, such as bacteria, yeast, or mammalian cells. The protein is then expressed and purified to obtain a highly pure and biologically active form of FSHR.

Activity of Recombinant Human FSHR Protein

Recombinant Human FSHR Protein is primarily involved in the regulation of reproductive processes. When FSH binds to the extracellular domain of FSHR, it causes a conformational change in the protein, leading to the activation of the G-protein signaling pathway. This results in the production of cAMP, which then stimulates the production of estrogen in the ovaries and sperm development in the testes.

In addition to its role in reproductive processes, Recombinant Human FSHR Protein has also been found to play a role in other physiological processes, such as bone formation and immune response. It has been shown to be expressed in osteoblasts, which are responsible for bone formation, and may play a role in regulating bone metabolism. FSHR has also been found to be expressed on immune cells, suggesting its involvement in the immune response.

Applications of Recombinant Human FSHR Protein

Recombinant Human FSHR Protein has various applications in both research and clinical settings. In research, it is used to study the role of FSHR in reproductive processes and other physiological processes. It is also used to develop assays for measuring FSH levels, as well as for screening potential drugs that target FSHR.

In clinical settings, Recombinant Human FSHR Protein is used as a diagnostic tool for evaluating fertility in both men and women. FSH levels can indicate the health and function of the ovaries and testes, and abnormalities in FSH levels can indicate fertility issues. In assisted reproductive technologies, such as in vitro fertilization, FSHR is targeted to stimulate the development of multiple follicles in the ovaries, increasing the chances of pregnancy.

In addition, Recombinant Human FSHR Protein is also being studied as a potential therapeutic target for various reproductive disorders, such as polycystic ovary syndrome and male infertility. By targeting FSHR, it may be possible to regulate reproductive processes and improve fertility in individuals with these disorders.

Conclusion

Recombinant Human FSHR Protein is a crucial protein involved in the regulation of reproductive processes. Its structure, activity, and applications have been extensively studied, and it continues to be a topic of interest in both research and clinical settings. With further research, this protein may hold the key to understanding and treating various reproductive