Recombinant Human HNRNPU Protein, N-His

Description of Recombinant Human HNRNPU Protein, N-His

Introduction

Recombinant Human HNRNPU Protein, also known as heterogeneous nuclear ribonucleoprotein U (HNRNPU), is a protein that plays a crucial role in various cellular processes, including gene expression, RNA processing, and protein synthesis. This protein is encoded by the HNRNPU gene and is found in the nucleus of human cells. In this article, we will explore the structure, activity, and applications of Recombinant Human HNRNPU Protein.

Structure of Recombinant Human HNRNPU Protein

Recombinant Human HNRNPU Protein is a 1289 amino acid protein with a molecular weight of approximately 145 kDa. It consists of three main domains: an N-terminal RNA recognition motif (RRM), a central glycine-rich domain, and a C-terminal acidic domain. The RRM domain is responsible for binding to RNA, while the glycine-rich domain is involved in protein-protein interactions. The acidic domain is thought to be important for the regulation of protein activity.

Activity of Recombinant Human HNRNPU Protein

Recombinant Human HNRNPU Protein is a multifunctional protein that plays a crucial role in various cellular processes. It is primarily known for its involvement in pre-mRNA processing, where it binds to nascent transcripts and helps in their splicing, polyadenylation, and export from the nucleus. This protein is also involved in the regulation of alternative splicing, which allows for the production of different protein isoforms from a single gene.

In addition to its role in RNA processing, Recombinant Human HNRNPU Protein has been shown to play a role in the regulation of gene expression. It has been found to bind to specific DNA sequences and regulate the transcription of target genes. This protein has also been implicated in the regulation of translation, where it interacts with ribosomes and modulates protein synthesis.

Applications of Recombinant Human HNRNPU Protein

Recombinant Human HNRNPU Protein has a wide range of applications in both research and therapeutic settings. One of the primary uses of this protein is in the study of RNA processing and gene expression. Its ability to bind to RNA and regulate splicing and transcription makes it a valuable tool for understanding the molecular mechanisms of these processes.

In addition, Recombinant Human HNRNPU Protein has been shown to be a potential diagnostic and prognostic marker for certain diseases. Studies have found altered expression of this protein in various cancers, including breast, lung, and ovarian cancer. It has also been linked to neurological disorders such as Alzheimer’s disease and autism spectrum disorders.

Furthermore, Recombinant Human HNRNPU Protein has therapeutic potential in the treatment of certain diseases. It has been shown to play a role in the development of drug resistance in cancer cells, making it a potential target for cancer therapy. Additionally, this protein has been found to interact with viral proteins, suggesting its potential as a target for antiviral therapies.

Conclusion

In conclusion, Recombinant Human HNRNPU Protein is a multifunctional protein that plays a crucial role in various cellular processes, including RNA processing, gene expression, and protein synthesis. Its structure, activity, and applications make it a valuable tool for understanding the molecular mechanisms of these processes and its potential as a diagnostic and therapeutic target. Further research on this protein will undoubtedly lead to a better understanding of its role in cellular function and its potential for disease treatment.