Recombinant Human HYAL2 Protein, N-His

Description of Recombinant Human HYAL2 Protein, N-His

Introduction

Recombinant Human HYAL2 Protein, also known as Hyaluronidase 2, is a protein that plays an important role in the breakdown of hyaluronic acid (HA) in the body. This protein is encoded by the HYAL2 gene and is involved in various physiological processes, including tissue remodeling, cell migration, and inflammation. In this article, we will discuss the structure, activity, and applications of Recombinant Human HYAL2 Protein.

Structure of Recombinant Human HYAL2 Protein

Recombinant Human HYAL2 Protein is a glycosylated protein that consists of 430 amino acids. It has a molecular weight of approximately 50 kDa and is composed of three domains: a signal peptide, a catalytic domain, and a C-terminal domain. The signal peptide is responsible for targeting the protein to the cell membrane, where it is anchored by a glycosylphosphatidylinositol (GPI) anchor. The catalytic domain contains the active site of the protein, which is responsible for the hydrolysis of HA. The C-terminal domain is thought to be involved in protein-protein interactions and may play a role in regulating the activity of HYAL2.

Activity of Recombinant Human HYAL2 Protein

The main function of Recombinant Human HYAL2 Protein is to degrade HA, a large polysaccharide that is found in the extracellular matrix of many tissues. HA is involved in various biological processes, such as cell adhesion, migration, and proliferation. However, excessive accumulation of HA can lead to tissue fibrosis and inflammation. HYAL2 breaks down HA into smaller fragments, which can then be further degraded by other enzymes. This process helps to maintain the balance of HA in the body and prevent pathological conditions associated with its overproduction.

HYAL2 has also been shown to have a role in cell signaling. It has been reported to interact with growth factor receptors, such as epidermal growth factor receptor (EGFR), and modulate their activity. This suggests that HYAL2 may have a broader role in regulating cellular processes beyond HA degradation.

Applications of Recombinant Human HYAL2 Protein

Recombinant Human HYAL2 Protein has a wide range of potential applications in both research and therapeutic settings. One of the major applications of this protein is in the study of HA metabolism and its role in various diseases. HYAL2 knockout mice have been used to study the physiological consequences of altered HA levels in the body. Recombinant HYAL2 protein can also be used in in vitro studies to investigate the effects of HYAL2 on cell signaling pathways and its potential as a therapeutic target.

Another potential application of Recombinant Human HYAL2 Protein is in the treatment of diseases associated with excessive HA accumulation. For example, HYAL2 has been shown to be downregulated in diseases such as cancer, osteoarthritis, and pulmonary fibrosis, where HA levels are elevated. Recombinant HYAL2 protein could potentially be used as a therapeutic agent to degrade excess HA and alleviate the symptoms of these diseases.

Conclusion

In summary, Recombinant Human HYAL2 Protein is a glycosylated protein that plays a crucial role in the breakdown of HA in the body. It has a unique structure with three distinct domains and has been shown to have both enzymatic and signaling activities. This protein has a wide range of potential applications in research and therapeutics, particularly in the study and treatment of diseases associated with altered HA levels. Further studies on the structure and function of HYAL2 may uncover new insights into its role in various physiological and pathological processes.