Recombinant Human IFT57 Protein, N-His-SUMO & C-Strep

Description of Recombinant Human IFT57 Protein, N-His-SUMO & C-Strep

Introduction

Recombinant Human IFT57 Protein, also known as Intraflagellar Transport Protein 57, is a key component of the intraflagellar transport (IFT) complex. This protein plays a crucial role in the formation and maintenance of cilia, which are hair-like structures found on the surface of many cells. In this article, we will explore the structure, activity, and application of Recombinant Human IFT57 Protein.

Structure of Recombinant Human IFT57 Protein

Recombinant Human IFT57 Protein is a 57 kDa protein composed of 506 amino acids. It is encoded by the IFT57 gene located on chromosome 4 in humans. The protein contains several functional domains, including a coiled-coil domain and a WD40 repeat domain. The coiled-coil domain is responsible for protein-protein interactions, while the WD40 repeat domain is involved in protein binding and assembly.

Activity of Recombinant Human IFT57 Protein

Recombinant Human IFT57 Protein is a crucial component of the IFT complex, which is responsible for the transport of proteins and other molecules along the ciliary axoneme. This transport is essential for the formation and maintenance of cilia, which play important roles in cell signaling, motility, and sensory perception.

The activity of Recombinant Human IFT57 Protein is regulated by various post-translational modifications, such as phosphorylation and acetylation. These modifications can affect the protein’s interactions with other components of the IFT complex, thus modulating its transport activity.

Application of Recombinant Human IFT57 Protein

Recombinant Human IFT57 Protein has various applications in both research and therapeutic fields. Its role in ciliary formation and maintenance makes it a valuable tool for studying ciliopathies, which are a group of disorders caused by defects in cilia. These disorders include polycystic kidney disease, Bardet-Biedl syndrome, and primary ciliary dyskinesia.

In addition, Recombinant Human IFT57 Protein has potential therapeutic applications in treating ciliopathies. For example, mutations in the IFT57 gene have been linked to Bardet-Biedl syndrome. By studying the structure and activity of Recombinant Human IFT57 Protein, researchers can develop targeted therapies to correct these mutations and potentially treat the disorder.

Furthermore, Recombinant Human IFT57 Protein can also be used in drug discovery and development. As cilia play important roles in various cellular processes, targeting IFT proteins such as IFT57 may lead to the development of new treatments for diseases such as cancer, diabetes, and obesity.

Conclusion

In summary, Recombinant Human IFT57 Protein is a crucial component of the IFT complex, involved in the transport of proteins and other molecules along the ciliary axoneme. Its structure and activity make it a valuable tool for studying ciliopathies and potential therapeutic target for various diseases. As research in this field continues to advance, Recombinant Human IFT57 Protein will play an important role in further understanding the functions of cilia and their potential applications in medicine.