Recombinant Human LAMB3 Protein, N-His

Description of Recombinant Human LAMB3 Protein, N-His

Introduction

Recombinant Human LAMB3 Protein, also known as Laminin subunit beta-3, is a protein that plays a crucial role in cell adhesion, migration, and differentiation. This protein is encoded by the LAMB3 gene and is a part of the Laminin family of proteins. Recombinant Human LAMB3 Protein is widely used in various scientific research and medical applications, making it a highly sought-after protein.

Structure of Recombinant Human LAMB3 Protein

Recombinant Human LAMB3 Protein is a large protein with a molecular weight of 160 kDa. It is composed of 1,159 amino acids and is organized into five distinct domains – the short arm of the Laminin G-like domain, the long arm of the Laminin G-like domain, the laminin N-terminal domain, the EGF-like domain, and the laminin-type EGF-like domain. These domains are important for the protein’s function and interactions with other molecules.

Activity of Recombinant Human LAMB3 Protein

Recombinant Human LAMB3 Protein is primarily known for its role in cell adhesion, which is the process by which cells attach to each other and to their surrounding environment. This protein helps in the formation and maintenance of cell adhesion structures, such as focal adhesions and hemidesmosomes. In addition, Recombinant Human LAMB3 Protein also plays a crucial role in cell migration, which is the movement of cells from one location to another. This protein helps in guiding cells to their intended destination by interacting with other proteins and signaling molecules.

Furthermore, Recombinant Human LAMB3 Protein is involved in cell differentiation, which is the process by which cells become specialized to perform specific functions. This protein helps in the differentiation of various cell types, including skin cells, nerve cells, and muscle cells. It also plays a role in tissue development and maintenance, as well as wound healing.

Application of Recombinant Human LAMB3 Protein

Recombinant Human LAMB3 Protein has a wide range of applications in scientific research and medical fields. One of its main uses is in cell culture studies, where it is used to coat cell culture dishes to promote cell adhesion and growth. This protein is also used in studies related to cell migration, differentiation, and tissue development.

In the medical field, Recombinant Human LAMB3 Protein is used in the treatment of a rare genetic disorder known as junctional epidermolysis bullosa (JEB). This disorder is caused by mutations in the LAMB3 gene, leading to a deficiency of functional LAMB3 protein. Recombinant Human LAMB3 Protein is used as a replacement therapy to restore the missing protein and improve the symptoms of JEB.

Moreover, Recombinant Human LAMB3 Protein is also being studied for its potential role in cancer treatment. This protein has been found to be overexpressed in various types of cancer, and its expression is associated with tumor growth and metastasis. Researchers are investigating the use of Recombinant Human LAMB3 Protein as a target for cancer therapy, with promising results.

Conclusion

In summary, Recombinant Human LAMB3 Protein is a vital protein with multiple functions in cell adhesion, migration, and differentiation. Its structure and activity make it an essential component in various cellular processes. The wide range of applications of this protein in scientific research and medical fields highlights its importance and potential for further study. With ongoing research, Recombinant Human LAMB3 Protein may hold even more promise for the treatment of various diseases and disorders.