Recombinant Human OVOL1 Protein, N-His

Description of Recombinant Human OVOL1 Protein, N-His

Introduction

Recombinant Human OVOL1 Protein, also known as OVO-like 1 protein, is a member of the zinc finger transcription factor family. It is encoded by the OVOL1 gene and is primarily expressed in the skin, lung, and stomach tissues. This protein plays a crucial role in regulating cell differentiation and proliferation, making it a promising target for various research and therapeutic applications.

Structure of Recombinant Human OVOL1 Protein

Recombinant Human OVOL1 Protein is a 384 amino acid protein with a molecular weight of approximately 43 kDa. It contains three C2H2-type zinc finger domains, which are crucial for its DNA-binding activity. These zinc finger domains are responsible for the specific recognition and binding of OVOL1 to target DNA sequences, thereby regulating the expression of target genes.

Activity of Recombinant Human OVOL1 Protein

Recombinant Human OVOL1 Protein plays a critical role in regulating cell differentiation and proliferation. It functions as a transcription factor, binding to specific DNA sequences and controlling the expression of target genes. OVOL1 has been shown to regulate the expression of various genes involved in cell adhesion, epithelial-mesenchymal transition, and cell cycle progression.

One of the key functions of OVOL1 is its role in maintaining the epithelial phenotype. It acts as a suppressor of epithelial-mesenchymal transition, a process where epithelial cells lose their characteristics and acquire a more migratory and invasive phenotype. OVOL1 achieves this by directly binding to the promoter regions of genes involved in epithelial-mesenchymal transition and inhibiting their expression.

In addition, OVOL1 also plays a role in regulating cell proliferation. It has been shown to suppress the expression of genes involved in cell cycle progression, thereby inhibiting cell proliferation. This function of OVOL1 is particularly important in the skin, where it helps maintain the balance between cell proliferation and differentiation, ensuring proper skin development and homeostasis.

Application of Recombinant Human OVOL1 Protein

Recombinant Human OVOL1 Protein has a wide range of applications in both research and therapeutic settings. Its role in regulating cell differentiation and proliferation makes it a valuable tool in studying various cellular processes and diseases.

In research, OVOL1 is commonly used as a recombinant protein for in vitro studies. Its DNA-binding activity allows for the identification of target genes and the study of their regulation. It is also used in cell culture experiments to study the effects of OVOL1 on cell proliferation and differentiation.

In therapeutic applications, OVOL1 has shown potential as a target for cancer treatment. Its role in suppressing epithelial-mesenchymal transition and cell proliferation makes it a promising candidate for inhibiting tumor growth and metastasis. Additionally, OVOL1 has been linked to various skin disorders, making it a potential target for the development of treatments for these conditions.

Conclusion

Recombinant Human OVOL1 Protein is a crucial player in regulating cell differentiation and proliferation. Its structure, activity, and various applications make it a valuable tool in both research and therapeutic settings. Further studies on OVOL1 and its role in various cellular processes and diseases may lead to the development of novel treatments for a wide range of conditions.