Recombinant Human PSMA4 Protein, N-His

Description of Recombinant Human PSMA4 Protein, N-His

Introduction

Recombinant Human PSMA4 Protein, also known as Prostate-Specific Membrane Antigen 4, is a protein that plays a crucial role in the development and progression of prostate cancer. This protein is encoded by the PSMA4 gene and is a member of the proteasome family. Recombinant Human PSMA4 Protein is widely used in research and diagnostic applications due to its unique structure and activity.

Structure of Recombinant Human PSMA4 Protein

Recombinant Human PSMA4 Protein is a 30-kilodalton protein that is composed of 277 amino acids. It is a type II transmembrane protein, which means that it has both an extracellular and an intracellular domain. The extracellular domain of Recombinant Human PSMA4 Protein contains a glycosylated region, which is responsible for its binding to other proteins and molecules. The intracellular domain, on the other hand, is responsible for the protein’s enzymatic activity.

Activity of Recombinant Human PSMA4 Protein

Recombinant Human PSMA4 Protein is a member of the proteasome family, which is a group of proteins that play a crucial role in the degradation of intracellular proteins. Specifically, this protein is a subunit of the 20S proteasome, which is responsible for the degradation of misfolded or damaged proteins. Recombinant Human PSMA4 Protein has been shown to have chymotrypsin-like activity, which means that it is able to cleave proteins at specific amino acid residues. This activity is essential for maintaining the integrity of the cell by removing damaged or unnecessary proteins.

Application of Recombinant Human PSMA4 Protein

1. Research: Recombinant Human PSMA4 Protein is widely used in research to study its role in prostate cancer. The protein is overexpressed in prostate cancer cells and has been shown to play a crucial role in the growth and survival of these cells. By studying the activity and structure of this protein, researchers can gain a better understanding of the mechanisms involved in prostate cancer development and progression.

2. Diagnostic tests: Recombinant Human PSMA4 Protein is also used in diagnostic tests for prostate cancer. The protein is present at high levels in the serum of patients with prostate cancer, making it a potential biomarker for the disease. Diagnostic tests that detect the presence of Recombinant Human PSMA4 Protein in the blood can aid in the early detection and diagnosis of prostate cancer.

3. Target for drug development: Due to its role in prostate cancer, Recombinant Human PSMA4 Protein is a potential target for drug development. Researchers are currently investigating the use of inhibitors that can block the activity of this protein, which could potentially lead to the development of new treatments for prostate cancer.

4. Production of antibodies: Recombinant Human PSMA4 Protein is also used in the production of antibodies for research and diagnostic purposes. Antibodies are proteins that can bind specifically to a target molecule, and they are essential tools in various laboratory techniques. By producing antibodies against Recombinant Human PSMA4 Protein, researchers can study its expression and function in different tissues and cell types.

Conclusion

Recombinant Human PSMA4 Protein is a 30-kilodalton protein that plays a crucial role in the development and progression of prostate cancer. It is a member of the proteasome family and has chymotrypsin-like activity, which is essential for the degradation of damaged or unnecessary proteins. This protein has various applications in research, diagnostics, and drug development, making it a valuable tool in the study of prostate cancer. Further research on Recombinant Human PSMA4 Protein could lead to a better understanding of its role in prostate cancer and the development of new treatments for the disease.