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AntibodySystem
Recombinant Proteins
Recombinant Human PSMC1, also known as 26S proteasome regulatory subunit 4, is a protein that plays a crucial role in the functioning of the 26S proteasome complex. This complex is responsible for the degradation of damaged or unwanted proteins in the cell, making it an essential component of cellular homeostasis. Recombinant Human PSMC1 is a synthetic version of the protein produced through genetic engineering techniques, making it a valuable tool in various scientific research and applications.
Recombinant Human PSMC1 is a 51 kDa protein consisting of 450 amino acids. It belongs to the AAA (ATPases associated with diverse cellular activities) family of proteins and contains six distinct domains – N-terminal domain, coiled-coil domain, AAA domain, linker domain, C-terminal domain, and a C-terminal tail. These domains work together to form a ring-shaped structure, which is essential for the function of the 26S proteasome complex.
The primary function of Recombinant Human PSMC1 is to act as a regulatory subunit of the 26S proteasome complex. It recognizes and binds to ubiquitinated proteins, marking them for degradation. The AAA domain of PSMC1 is responsible for ATPase activity, which provides the energy required for the proteasome complex to unfold and degrade the targeted proteins. Additionally, Recombinant Human PSMC1 also plays a role in the assembly and stability of the 26S proteasome complex.
Recombinant Human PSMC1 is widely used in research to study the mechanism of protein degradation in the cell. It can be used to investigate the role of the 26S proteasome complex in various cellular processes, such as cell cycle regulation, DNA repair, and immune response. Its ability to recognize and bind to ubiquitinated proteins makes it a valuable tool in understanding the specificity of protein degradation.
The 26S proteasome complex is a target for many drugs, particularly in the treatment of cancer. Recombinant Human PSMC1 can be used to screen potential drug candidates that can inhibit the activity of the proteasome complex. This can aid in the development of new and more effective drugs for the treatment of various diseases.
Recombinant Human PSMC1 can also be used as an antigen to produce specific antibodies. These antibodies can then be used in various immunoassays to detect the presence of PSMC1 in different samples. This is particularly useful in diagnosing diseases that are associated with dysregulation of the 26S proteasome complex.
Recombinant Human PSMC1 is also used in biotechnology applications, such as protein purification and production. It can be expressed in various expression systems, including bacteria, yeast, and mammalian cells, to produce large quantities of the protein for research or commercial purposes.
Abnormalities in the expression or function of the 26S proteasome complex have been linked to various diseases, including cancer and neurodegenerative disorders. Recombinant Human PSMC1 can be used as a diagnostic tool to detect these abnormalities in patient samples, aiding in the early detection and treatment of these diseases.
Recombinant Human PSMC1 has also shown potential as a therapeutic agent for certain diseases. Studies have shown that it can inhibit the growth of
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