Recombinant Human RAB39B Protein, N-His

Description of Recombinant Human RAB39B Protein, N-His

Introduction to Recombinant Human RAB39B Protein

Recombinant Human RAB39B Protein is a highly purified and biologically active protein that is produced through recombinant DNA technology. This protein is a member of the RAB family of small GTPases and plays a crucial role in intracellular vesicle trafficking and membrane trafficking processes. In this article, we will explore the structure, activity, and applications of Recombinant Human RAB39B Protein.

Structure of Recombinant Human RAB39B Protein

Recombinant Human RAB39B Protein is a 23 kDa protein that consists of 202 amino acids. It is composed of a conserved GTP-binding domain, a flexible switch I region, and a C-terminal hypervariable region. The GTP-binding domain is responsible for binding to guanine nucleotides and regulating the activity of the protein. The switch I region is involved in the conformational changes that occur upon GTP binding, while the C-terminal hypervariable region interacts with downstream effector molecules.

Activity of Recombinant Human RAB39B Protein

Recombinant Human RAB39B Protein is a key regulator of vesicle trafficking and membrane trafficking processes. It is primarily involved in the transport of proteins and lipids between different cellular compartments. This protein acts as a molecular switch, cycling between an active GTP-bound form and an inactive GDP-bound form. The GTP-bound form interacts with downstream effector proteins, while the GDP-bound form is inactive.

The activity of Recombinant Human RAB39B Protein is also regulated by a variety of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). GEFs promote the exchange of GDP for GTP, leading to the activation of the protein, while GAPs stimulate the intrinsic GTPase activity, resulting in the inactivation of the protein.

Applications of Recombinant Human RAB39B Protein

Recombinant Human RAB39B Protein has a wide range of applications in both basic research and drug discovery. It is commonly used as an antigen in immunological studies to generate specific antibodies against RAB39B. These antibodies can then be used for protein detection and localization studies in various cell types and tissues.

In addition, Recombinant Human RAB39B Protein has been implicated in several human diseases, including neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease. Studies have shown that mutations in the RAB39B gene can lead to impaired vesicle trafficking and contribute to the pathogenesis of these diseases. Therefore, Recombinant Human RAB39B Protein is a valuable tool for studying the molecular mechanisms underlying these disorders.

Furthermore, Recombinant Human RAB39B Protein has potential therapeutic applications. It has been shown to interact with various proteins involved in cancer progression, making it a potential target for cancer therapy. Additionally, it has been reported to play a role in immune response regulation, suggesting its potential use in the treatment of autoimmune diseases.

Conclusion

In summary, Recombinant Human RAB39B Protein is a crucial player in intracellular vesicle trafficking and membrane trafficking processes. Its structure, activity, and applications make it a valuable tool for various research areas, including immunology, neurodegenerative diseases, and cancer. With its potential therapeutic applications, this protein holds promise for the development of novel treatments for various diseases.