Recombinant Human RARRES2, N-His

Description of Recombinant Human RARRES2, N-His

Introduction to Recombinant Human RARRES2

Recombinant Human RARRES2, also known as Retinoic Acid Receptor Responder Protein 2, is a protein that is encoded by the RARRES2 gene in humans. This gene is located on chromosome 7 and is involved in the regulation of various cellular processes, such as cell growth, differentiation, and apoptosis. Recombinant Human RARRES2 is a synthetic form of this protein that is produced through genetic engineering techniques, making it an important tool in scientific research and medical applications.

Structure of Recombinant Human RARRES2

The structure of Recombinant Human RARRES2 is composed of 135 amino acids, with a molecular weight of approximately 15 kDa. It contains a conserved cysteine-rich domain, which is believed to play a role in protein-protein interactions. This domain is essential for the binding of RARRES2 to its receptor, the retinoic acid receptor (RAR), and is therefore crucial for its biological activity.

Recombinant Human RARRES2 also contains a signal peptide at its N-terminus, which is responsible for directing the protein to the endoplasmic reticulum for proper folding and post-translational modifications. These modifications, such as glycosylation, ensure the stability and functionality of the protein.

Activity of Recombinant Human RARRES2

Recombinant Human RARRES2 is a multifunctional protein that has been shown to have various activities in different biological processes. One of its main functions is its role as a retinoic acid-responsive gene, which is activated by retinoic acid (RA) binding to its receptor RAR. This activation leads to the upregulation of RARRES2 expression, which in turn induces cell differentiation and inhibits cell proliferation.

In addition to its role in cell growth and differentiation, Recombinant Human RARRES2 has also been found to have anti-inflammatory and anti-tumor properties. It has been shown to inhibit the production of pro-inflammatory cytokines and chemokines, as well as suppress the growth and invasion of cancer cells. This makes it a potential therapeutic target for diseases such as cancer and inflammatory disorders.

Application of Recombinant Human RARRES2

The unique structure and activity of Recombinant Human RARRES2 make it a valuable tool in various scientific and medical applications. One of its main uses is in studying the role of RARRES2 in different biological processes. By overexpressing or silencing the gene that encodes this protein, researchers can better understand its function and potential therapeutic implications.

Recombinant Human RARRES2 is also used in drug discovery and development. Its ability to inhibit cell proliferation and induce differentiation makes it a potential target for anti-cancer drugs. Additionally, its anti-inflammatory properties make it a promising candidate for the treatment of inflammatory diseases, such as rheumatoid arthritis and psoriasis.

Furthermore, Recombinant Human RARRES2 has diagnostic applications. It has been found to be upregulated in certain types of cancer, such as breast and lung cancer, making it a potential biomarker for early detection and monitoring of these diseases.

Conclusion

In summary, Recombinant Human RARRES2 is a synthetic form of the RARRES2 protein that has a conserved cysteine-rich domain and a signal peptide for proper folding and post-translational modifications. It has various activities, including its role as a retinoic acid-responsive gene, anti-inflammatory and anti-tumor properties. This makes it a valuable tool in scientific research and has potential applications in drug development and diagnostics. Further studies on this protein may lead to new insights and advancements in various fields of medicine.