Recombinant Human SAMM50 Protein, N-His

Description of Recombinant Human SAMM50 Protein, N-His

Introduction

Recombinant Human SAMM50 Protein is a highly purified and bioactive protein that is produced through recombinant DNA technology. This protein plays a crucial role in the structure and function of mitochondria, the powerhouse of the cell. In this article, we will discuss the structure, activity and potential applications of Recombinant Human SAMM50 Protein.

Structure of Recombinant Human SAMM50 Protein

Recombinant Human SAMM50 Protein is a 50-kDa protein that is composed of 434 amino acids. It is a transmembrane protein that is located in the outer membrane of mitochondria. The protein has a highly conserved SAM (sterile alpha motif) domain, which is important for protein-protein interactions. SAMM50 also contains a C-terminal domain that is essential for its localization to the mitochondrial outer membrane.

Activity of Recombinant Human SAMM50 Protein

SAMM50 is a crucial component of the mitochondrial protein import machinery. It plays a critical role in the assembly and stability of the mitochondrial protein translocase complex, which is responsible for transporting proteins from the cytosol into the mitochondria. SAMM50 forms a complex with other proteins, such as TOM40 and TOM22, to facilitate the import of precursor proteins into the mitochondria.

In addition to its role in protein import, SAMM50 also plays a role in mitochondrial dynamics. It interacts with proteins involved in mitochondrial fusion and fission, such as MFN1 and DRP1, to regulate the shape and size of mitochondria. SAMM50 also plays a role in maintaining the integrity of the mitochondrial outer membrane, which is important for the proper functioning of the organelle.

Applications of Recombinant Human SAMM50 Protein

Recombinant Human SAMM50 Protein has a wide range of potential applications in both research and clinical settings. Its role in mitochondrial protein import makes it a valuable tool for studying mitochondrial dysfunction and related diseases. Mutations in SAMM50 have been linked to neurodegenerative disorders, such as Parkinson’s disease and Alzheimer’s disease, making it a potential target for therapeutic interventions.

Furthermore, SAMM50 has been shown to be involved in the development and progression of cancer. Its overexpression has been observed in various types of cancer, including breast, colon, lung, and ovarian cancer. This makes it a potential biomarker for cancer diagnosis and a target for anti-cancer therapies.

In addition, recombinant SAMM50 protein can be used in in vitro studies to investigate its role in mitochondrial dynamics and function. It can also be used to screen for potential drugs that can modulate its activity, which can lead to the development of new treatments for mitochondrial disorders and cancer.

Conclusion

In summary, Recombinant Human SAMM50 Protein is a key player in the structure and function of mitochondria. Its role in protein import and mitochondrial dynamics makes it a crucial component of the organelle. Its potential applications in research and medicine make it a valuable tool for studying and treating various diseases. With further research, SAMM50 could potentially lead to new therapeutic strategies for mitochondrial disorders and cancer.