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Recombinant Proteins
Recombinant Human SNX3 Protein, also known as Sorting Nexin 3, is a protein that plays a crucial role in the process of endosomal sorting and trafficking. It belongs to the SNX family of proteins, which are involved in the regulation of membrane trafficking and protein sorting within cells. Recombinant Human SNX3 Protein is a highly studied and well-characterized protein, with various applications in both basic research and clinical settings.
Recombinant Human SNX3 Protein is a 25 kDa protein composed of 219 amino acids. It contains a Phox homology (PX) domain, which is responsible for its interaction with phospholipids and membrane proteins. The PX domain is followed by a coiled-coil region, which mediates protein-protein interactions. The C-terminal region of the protein contains a Bin-Amphiphysin-Rvs (BAR) domain, which is involved in membrane curvature sensing and generation. The structure of Recombinant Human SNX3 Protein allows it to interact with various cellular components and participate in different cellular processes.
Recombinant Human SNX3 Protein is primarily involved in the process of endosomal sorting and trafficking. It is recruited to early endosomes, where it interacts with phosphatidylinositol 3-phosphate (PI3P) through its PX domain. This interaction is essential for the recruitment of other endosomal sorting machinery and the formation of endosomal tubules. These tubules are responsible for the sorting of cargo proteins and lipids into different endosomal compartments. Recombinant Human SNX3 Protein also plays a role in the maturation of late endosomes and the fusion of endosomes with lysosomes.
In addition to its role in endosomal sorting, Recombinant Human SNX3 Protein has been shown to be involved in other cellular processes. It has been implicated in the regulation of cell migration and invasion, as well as in the formation of filopodia and lamellipodia. This is due to its ability to interact with actin-binding proteins and modulate actin dynamics. Moreover, Recombinant Human SNX3 Protein has been shown to regulate the activity of various signaling pathways, such as the Wnt and TGF-β pathways, through its interactions with specific membrane proteins.
Recombinant Human SNX3 Protein has a wide range of applications in both basic research and clinical settings. In basic research, it is used to study the process of endosomal sorting and trafficking. Its interactions with various cellular components make it a valuable tool for understanding the mechanisms involved in these processes. Recombinant Human SNX3 Protein is also used to study its role in other cellular processes, such as cell migration and signaling pathways. Its ability to modulate these processes makes it a promising target for drug development.
In clinical settings, Recombinant Human SNX3 Protein has been implicated in various diseases. Mutations in the SNX3 gene have been linked to neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. Recombinant Human SNX3 Protein is also being studied as a potential therapeutic target for cancer. Its role in regulating cell migration and invasion makes it a promising target for the development of anti-cancer drugs. Moreover, Recombinant Human SNX3 Protein has been shown to play a role in viral infection, making it a potential target for antiviral therapies.
In conclusion, Recombinant Human SNX3 Protein is a highly studied and well-characterized protein that plays a crucial role in endosomal sorting and trafficking. Its structure allows it to interact with various cellular components and participate in different cellular processes. Recombinant Human SNX3 Protein has various applications in both basic research and clinical settings, and its potential as a therapeutic target makes it an exciting area of research. Further studies on this protein will provide
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