Recombinant Human TREM2 Protein, N-His-SUMO

Description of Recombinant Human TREM2 Protein, N-His-SUMO

Introduction

Recombinant Human TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) Protein is a protein that is produced through genetic engineering techniques in a laboratory setting. It is a soluble protein that is derived from the TREM2 gene, which is located on chromosome 6 in humans. This protein plays a crucial role in the immune system and has been linked to various diseases, making it a valuable tool in biomedical research and potential therapeutic applications.

Structure of Recombinant Human TREM2 Protein

The recombinant human TREM2 protein is composed of 230 amino acids with a molecular weight of approximately 25 kDa. It is a type I transmembrane protein, meaning that it spans the cell membrane with a short intracellular domain and a longer extracellular domain. The extracellular domain is where the protein interacts with other molecules and is responsible for its biological activity.

The extracellular domain of TREM2 contains an immunoglobulin-like domain and a stalk region. The immunoglobulin-like domain is responsible for binding to its ligands, while the stalk region provides flexibility for the protein to interact with other molecules. The intracellular domain of TREM2 is involved in signal transduction, which is necessary for the activation of immune cells.

Activity of Recombinant Human TREM2 Protein

The main function of TREM2 is to regulate the activity of immune cells, specifically myeloid cells such as macrophages and microglia. These cells play a crucial role in the immune response by engulfing and destroying foreign substances, damaged cells, and cellular debris. TREM2 acts as a receptor on the surface of these cells, binding to specific ligands and triggering a signaling cascade that leads to the activation of the cells.

Studies have shown that TREM2 is involved in various cellular processes, including phagocytosis, cell survival, and inflammation. It has also been linked to the regulation of lipid metabolism and the maintenance of brain function. Dysregulation of TREM2 has been implicated in several diseases, including Alzheimer’s disease, multiple sclerosis, and cancer.

Application of Recombinant Human TREM2 Protein

Recombinant Human TREM2 Protein has various applications in biomedical research and potential therapeutic interventions. It is commonly used as an antigen in studies to understand the role of TREM2 in different diseases. The recombinant protein can be used to generate antibodies that specifically target TREM2, allowing researchers to study its expression, function, and regulation in different cell types and disease models.

Additionally, recombinant human TREM2 protein can be used in drug discovery and development. As TREM2 is involved in the regulation of immune cells and inflammation, it has been identified as a potential target for therapeutic intervention in diseases such as Alzheimer’s and multiple sclerosis. Recombinant protein can be used to screen for small molecules or biologics that can modulate TREM2 activity and potentially treat these diseases.

Furthermore, recombinant human TREM2 protein can be used in the development of diagnostic tests for diseases that are associated with TREM2 dysregulation. By detecting the levels of TREM2 in biological samples, these tests can aid in the early diagnosis and monitoring of diseases such as Alzheimer’s and cancer.

Conclusion

In summary, Recombinant Human TREM2 Protein is a valuable tool in biomedical research and has potential applications in therapeutic interventions and diagnostics. Its unique structure and activity make it an essential protein in the regulation of immune cells and maintenance of cellular function. Further studies on TREM2 and its recombinant form will continue to expand our understanding of its role in health and disease.