Recombinant Mouse C1ra Protein, N-His

Description of Recombinant Mouse C1ra Protein, N-His

Introduction

Recombinant Mouse C1ra Protein, also known as Complement Component 1 Inhibitor, is a genetically engineered protein that is derived from the mouse C1ra gene. This protein plays a crucial role in regulating the activity of the complement system, which is a key component of the immune system. In this article, we will explore the structure, activity, and applications of Recombinant Mouse C1ra Protein.

Structure of Recombinant Mouse C1ra Protein

Recombinant Mouse C1ra Protein is a single-chain glycoprotein that consists of 478 amino acids. It contains a signal peptide at the N-terminus, followed by an activation peptide and a serine protease domain. The serine protease domain is responsible for the inhibitory activity of C1ra, as it binds to and inactivates the complement component C1r. The C-terminus of the protein contains a CUB (complement C1r/C1s, Uegf, Bmp1) domain, which is involved in the recognition and binding of substrates.

Activity of Recombinant Mouse C1ra Protein

The main function of Recombinant Mouse C1ra Protein is to regulate the activity of the complement system. The complement system is a complex cascade of proteins that helps in the clearance of pathogens and damaged cells from the body. However, an overactive complement system can also cause tissue damage and inflammation. This is where C1ra comes into play, as it acts as an inhibitor of the complement system and prevents its excessive activation.

Recombinant Mouse C1ra Protein specifically inhibits the activity of C1r, which is the first component of the classical pathway of the complement system. C1r is responsible for the activation of the complement component C1s, which in turn activates the downstream components of the complement cascade. By binding to and inactivating C1r, C1ra effectively blocks the initiation of the classical pathway, thus preventing the overactivation of the complement system.

Applications of Recombinant Mouse C1ra Protein

The unique inhibitory activity of Recombinant Mouse C1ra Protein makes it a valuable tool for various research and therapeutic applications. Here are some of its key applications:

Research

Recombinant Mouse C1ra Protein is widely used in research studies to investigate the role of the complement system in various diseases and conditions. It is particularly useful in studying autoimmune disorders, where an overactive complement system is often implicated. C1ra can also be used to study the pathogenesis of inflammatory diseases, as it helps in controlling the inflammatory response.

Therapeutic

The inhibitory activity of Recombinant Mouse C1ra Protein makes it a potential therapeutic agent for the treatment of complement-mediated diseases. For example, it can be used to treat hereditary angioedema, a rare genetic disorder caused by a deficiency of C1 inhibitor, which leads to excessive activation of the complement system. C1ra can also be used to treat other conditions where complement overactivation is involved, such as sepsis and ischemia-reperfusion injury.

Diagnostic

Recombinant Mouse C1ra Protein can also be used in diagnostic tests to measure the activity of the complement system. Its inhibitory activity can be measured in patient samples to assess the level of complement activation, which can be indicative of certain diseases or conditions.

Conclusion

Recombinant Mouse C1ra Protein is a valuable tool in the study and treatment of complement-mediated diseases. Its unique structure and inhibitory activity make it an important protein in regulating the activity of the complement system. With ongoing research and development, this protein holds great potential for future therapeutic and diagnostic applications.