Recombinant Mouse CTSH Protein, N-His

Description of Recombinant Mouse CTSH Protein, N-His

Introduction

Recombinant Mouse CTSH Protein, also known as Cathepsin H, is a type of recombinant protein that has been widely studied for its structure, activity, and potential applications. This protein is a member of the cathepsin family, which are a group of lysosomal proteases involved in various cellular processes. Recombinant Mouse CTSH Protein has been found to play a crucial role in immune response, antigen presentation, and cancer progression.

Structure of Recombinant Mouse CTSH Protein

Recombinant Mouse CTSH Protein is a 37 kDa protein that is composed of 333 amino acids. It is a member of the papain superfamily of cysteine proteases, which are characterized by a conserved catalytic triad of amino acids (cysteine, histidine, and asparagine). The protein has a signal peptide at the N-terminus, which is important for its secretion and targeting to the lysosomes. It also contains a propeptide region that is removed during maturation to activate the protein.

Activity of Recombinant Mouse CTSH Protein

Recombinant Mouse CTSH Protein is primarily known for its proteolytic activity, which is involved in the breakdown of proteins in the lysosomes. It has been found to have a preference for cleaving peptide bonds after basic amino acids, such as arginine and lysine. This activity is important for the degradation of foreign proteins, such as pathogens, as well as for the turnover of cellular proteins.

In addition to its proteolytic activity, Recombinant Mouse CTSH Protein also has a role in antigen processing and presentation. It is involved in the cleavage of antigens into smaller peptides, which are then presented on the surface of antigen-presenting cells to activate the immune response. This process is essential for the recognition and elimination of foreign invaders by the immune system.

Application of Recombinant Mouse CTSH Protein

Recombinant Mouse CTSH Protein has been studied for its potential therapeutic applications in various diseases, particularly in cancer. It has been found to be overexpressed in many types of cancer, including breast, lung, and colon cancer. This overexpression has been linked to tumor progression and metastasis, making Recombinant Mouse CTSH Protein a potential target for cancer treatment.

Furthermore, Recombinant Mouse CTSH Protein has been found to have a role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In these diseases, the protein is involved in the degradation of self-antigens, leading to the activation of the immune response against the body’s own tissues. Inhibiting the activity of Recombinant Mouse CTSH Protein could potentially help in managing these autoimmune diseases.

Moreover, Recombinant Mouse CTSH Protein has been studied for its potential as a biomarker for various diseases. Its overexpression in cancer and autoimmune diseases makes it a promising candidate for diagnostic and prognostic purposes. Additionally, the protein has been found to be involved in the development of atherosclerosis, making it a potential biomarker for cardiovascular diseases.

Conclusion

Recombinant Mouse CTSH Protein is a 37 kDa protein that plays a crucial role in immune response, antigen presentation, and cancer progression. Its structure, activity, and potential applications have been extensively studied, making it a promising target for therapeutic interventions and biomarker discovery. Further research on this protein could lead to a better understanding of its functions and potential clinical applications.