Recombinant Mouse IL27RA Protein, N-His

Description of Recombinant Mouse IL27RA Protein, N-His

Introduction

Recombinant Mouse IL27RA Protein is a highly purified, bioactive protein that is derived from genetic engineering techniques. It is a member of the interleukin-6 cytokine family and plays a crucial role in regulating immune responses.

Structure

The recombinant protein is composed of 486 amino acids with a molecular weight of approximately 55 kDa. It is a heterodimeric protein, consisting of two subunits: IL27RA and IL6ST. The IL27RA subunit is the receptor for IL27, while the IL6ST subunit is shared with other cytokine receptors in the family.

Activity

Recombinant Mouse IL27RA Protein has been shown to have both pro- and anti-inflammatory properties. It acts as a ligand for IL27, which is a potent inducer of Th1 cell differentiation and pro-inflammatory cytokine production. This leads to the activation of immune cells, such as T cells and natural killer cells, and the production of interferon-gamma (IFN-γ).

On the other hand, IL27RA also has anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines, such as IL-6 and IL-17. It can also induce the production of anti-inflammatory cytokines, such as IL-10, which helps to regulate the immune response and maintain immune homeostasis.

Overall, the activity of recombinant mouse IL27RA protein is essential for maintaining a balanced immune response and preventing excessive inflammation.

Application

Recombinant Mouse IL27RA Protein has a wide range of applications in both research and therapeutic settings. Some of the key applications include:

• Cancer Research: IL27RA has been shown to have anti-tumor effects by inhibiting the growth of cancer cells and promoting the activation of immune cells to attack tumors. Recombinant protein can be used in cancer research to study these effects and potentially develop new cancer treatments.
• Inflammation and Autoimmune Diseases: As mentioned earlier, IL27RA has both pro- and anti-inflammatory effects, making it a potential target for treating autoimmune diseases. Recombinant protein can be used to study the role of IL27RA in these diseases and develop new therapies.
• Infectious Diseases: IL27RA is involved in the immune response against viral and bacterial infections. Recombinant protein can be used to study the mechanisms of immune defense against these pathogens and potentially develop new treatments.
• Immunotherapy: Recombinant Mouse IL27RA Protein has been used in preclinical studies as a potential immunotherapy for cancer and autoimmune diseases. It has shown promising results in regulating the immune response and inhibiting tumor growth, making it a potential candidate for future immunotherapies.

Conclusion

In summary, Recombinant Mouse IL27RA Protein is a vital tool for studying the role of IL27RA in immune regulation and developing new therapies for various diseases. Its unique structure and diverse activities make it a valuable protein in the field of immunology and beyond.