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View ProductsSize | 100ug |
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Brand | Arovia |
Product type | Recombinant Proteins |
Product name | Recombinant Mouse PADI2 Protein, N-Strep |
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Origin species | Mouse |
Expression system | Eukaryotic expression |
Molecular weight | 80 kDa |
Buffer | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
Form | Liquid |
Delivery condition | Dry Ice |
Delivery lead time in business days | 3-5 days if in stock; 3-5 weeks if production needed |
Storage condition | 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection) |
Brand | Arovia |
Host species | Insect |
Fragment Type | Met1-Pro673 |
Aliases /Synonyms | Protein-arginine deiminase type-2, 3.5.3.15, Peptidylarginine deiminase II, Protein-arginine deiminase type II, Padi2, Pad2, Pdi, Pdi2 |
Reference | EMK12001 |
Note | For research use only. |
Recombinant proteins are proteins that are produced through genetic engineering techniques, where the gene for a particular protein is inserted into a host organism, such as bacteria or yeast, to produce large quantities of that protein. Recombinant proteins have become an essential tool in various scientific fields, including biotechnology, medicine, and research. One such recombinant protein is Recombinant Mouse PADI2 Protein, which has gained significant attention due to its diverse structural and functional properties.
Recombinant Mouse PADI2 Protein, also known as Peptidylarginine deiminase 2, is a member of the peptidylarginine deiminase family of enzymes. It is a calcium-dependent enzyme that plays a crucial role in post-translational modifications of proteins by catalyzing the conversion of arginine residues to citrulline. The recombinant protein is composed of 663 amino acids and has a molecular weight of approximately 74 kDa. It contains two calcium-binding EF-hand domains, which are essential for its enzymatic activity.
Recombinant Mouse PADI2 Protein is primarily involved in the process of citrullination, which is the conversion of the amino acid arginine to citrulline. This process plays a crucial role in various physiological and pathological processes, such as gene regulation, cell signaling, and autoimmune diseases. The enzymatic activity of Recombinant Mouse PADI2 Protein is calcium-dependent, where the binding of calcium ions to the EF-hand domains activates the enzyme. It has been shown to have a broad substrate specificity, with a preference for arginine residues in histones and other nuclear proteins.
Recombinant Mouse PADI2 Protein has various applications in both research and medicine. One of its primary uses is in the study of post-translational modifications of proteins, particularly citrullination. Its ability to catalyze the conversion of arginine to citrulline makes it a valuable tool in understanding the role of citrullination in various biological processes. Additionally, Recombinant Mouse PADI2 Protein has been used in the production of citrullinated peptides for use in diagnostic tests for autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.
Furthermore, Recombinant Mouse PADI2 Protein has potential therapeutic applications. It has been shown to play a role in the progression of various diseases, such as cancer and neurodegenerative disorders. Inhibition of its activity has been explored as a potential treatment strategy for these diseases. Recombinant Mouse PADI2 Protein has also been used in drug development studies, where it is used to screen and identify potential inhibitors of its activity.
Recombinant Mouse PADI2 Protein is a calcium-dependent enzyme that plays a crucial role in post-translational modifications of proteins. Its structural and functional properties make it a valuable tool in various scientific fields, including research and medicine. Its diverse applications, ranging from the study of citrullination to potential therapeutic uses, highlight its significance in the scientific community. With ongoing research and advancements in recombinant protein technology, Recombinant Mouse PADI2 Protein is expected to continue to contribute to our understanding of biological processes and potential treatments for various diseases.
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