Recombinant Mouse RGMB Protein, N-His

Description of Recombinant Mouse RGMB Protein, N-His

Introduction to Recombinant Mouse RGMB Protein

Recombinant Mouse RGMB Protein is a highly versatile protein that plays a crucial role in various biological processes. This protein is produced through recombinant DNA technology, which involves combining genetic material from different sources to create a new protein. Recombinant Mouse RGMB Protein is widely used in research and clinical applications due to its unique structure, activity, and applications.

Structure of Recombinant Mouse RGMB Protein

Recombinant Mouse RGMB Protein is a glycosylated protein that belongs to the repulsive guidance molecule (RGM) family. It is composed of 346 amino acids and has a molecular weight of approximately 38 kDa. The protein structure consists of a signal peptide, a C-terminal domain, and an N-terminal domain. The N-terminal domain is responsible for binding to its receptor, neogenin, while the C-terminal domain is involved in protein-protein interactions.

The recombinant protein is produced in a mammalian expression system, ensuring proper folding and post-translational modifications. This results in a highly pure and biologically active protein that closely resembles the native protein found in the body.

Activity of Recombinant Mouse RGMB Protein

Recombinant Mouse RGMB Protein has been shown to have diverse biological activities. It is primarily known for its role as a repulsive guidance molecule, which helps in the development and maintenance of the nervous system. This protein is involved in axon guidance, neuronal migration, and synapse formation.

In addition to its role in the nervous system, Recombinant Mouse RGMB Protein also has anti-angiogenic properties. It inhibits the formation of new blood vessels, making it a potential therapeutic target for diseases such as cancer and diabetic retinopathy. Studies have also shown that this protein has anti-inflammatory effects, making it a promising candidate for the treatment of inflammatory diseases.

Applications of Recombinant Mouse RGMB Protein

The unique structure and activity of Recombinant Mouse RGMB Protein make it a valuable tool in various research and clinical applications. Its ability to bind to neogenin and modulate its signaling pathway has made it a popular protein for studying nervous system development and function.

Recombinant Mouse RGMB Protein is also used in drug discovery and development. Its anti-angiogenic and anti-inflammatory properties make it a potential therapeutic target for various diseases. Researchers are currently investigating the use of this protein in the treatment of cancer, diabetic retinopathy, and other inflammatory conditions.

Moreover, Recombinant Mouse RGMB Protein is used in diagnostic assays to detect the presence of neogenin in biological samples. This can help in the diagnosis of diseases related to the nervous system, as well as cancer and inflammatory conditions.

Conclusion

In summary, Recombinant Mouse RGMB Protein is a highly versatile protein with a unique structure and diverse biological activities. Its role in the nervous system, as well as its anti-angiogenic and anti-inflammatory properties, make it a valuable tool in research and a potential therapeutic target for various diseases. The use of this protein in diagnostic assays further highlights its importance in the field of biomedicine. With ongoing research and advancements in recombinant DNA technology, the potential applications of Recombinant Mouse RGMB Protein are vast and promising.