VSVG Protein- Vesicular stomatitis virus VSVG IND1 Recombinant Protein

Description of VSVG Protein- Vesicular stomatitis virus VSVG IND1 Recombinant Protein

General information on VSVG IND1

VSVG IND1 is a subtype of Vesicular stomatitis virus (VSV) family of glycoproteins. The latter mediate both cell attachment and membrane fusion. Unlike many other low-pH-induced viral fusion proteins, VSV glycoproteins deliver reversible fusogenic conformational transitions. VSV-G has a three-stage fusion kinetics:
• G-protein conformational change which is reversible and pH-dependent.
• Reversible trimerization and clustering of the G-protein fusion loops.
• Folding back of a cluster of extended trimers into their post-fusion conformations.
VSV NJ glycoprotein contains 517 amino acids and is glycosylated at position 178 and 335. Unlike VSV Indiana (VSIV), another major serotype of VSV, VSV NJ is not acylated. The two serotypes also differentiate in terms of antigenic structure. VSV NJ has a faster glycoprotein folding intracellularly and with less dependence on glycosylation.